Chem Catalysis, Год журнала: 2024, Номер unknown, С. 101159 - 101159
Опубликована: Ноя. 1, 2024
Язык: Английский
Chem Catalysis, Год журнала: 2024, Номер unknown, С. 101159 - 101159
Опубликована: Ноя. 1, 2024
Язык: Английский
Nature, Год журнала: 2023, Номер 623(7985), С. 66 - 70
Опубликована: Сен. 20, 2023
Язык: Английский
Процитировано
28Journal of the American Chemical Society, Год журнала: 2024, Номер 146(5), С. 2933 - 2938
Опубликована: Янв. 22, 2024
Most of the known single-electron reductants are either metal based reagents, used in a stoichiometric amount, or combination an organic species and photocatalyst. Here we report that 1
Язык: Английский
Процитировано
13Organic Letters, Год журнала: 2022, Номер 24(32), С. 5913 - 5917
Опубликована: Авг. 4, 2022
An N-heterocyclic carbene-catalyzed oxidant-, metal- and light-free iminyl radical generation pathway stemming from the reaction of vinyl azide α-bromo ester is uncovered. This newly developed methodology successfully applied to redox-neutral construction a number diversified phenanthridine derivatives with nice functional group compatibility. Insights mechanism study reveal that this NHC-catalyzed transformation potentially proceeds through an alkyl addition-initiated HAS process, as active intermediate.
Язык: Английский
Процитировано
29Organic Letters, Год журнала: 2022, Номер 24(41), С. 7654 - 7658
Опубликована: Окт. 11, 2022
A variety of phenanthridines are rapidly constructed by an N-heterocyclic carbene (NHC)-catalyzed SOMOphilic isocyanide insertion-initiated homolytic aromatic substitution-type radical cyclization in the absence any light, transition metals, and external oxidants. The aldehyde-free, scalable, operationally simple protocol tolerates diverse functionalized biaryl isonitriles activated α-halides. Moreover, it can be further applied to divergent construction other N-heterocycles. Preliminary mechanistic studies disclose that NHC-derived cation intermediate is possibly involved.
Язык: Английский
Процитировано
20Organic Letters, Год журнала: 2023, Номер 25(32), С. 6072 - 6076
Опубликована: Авг. 8, 2023
A novel and efficient strategy for the synthesis of a series structurally interesting benzazepine derivatives via an N-heterocyclic carbene-catalyzed regioselective intramolecular radical cyclization has been developed. This protocol features good regioselectivity, functional-group compatibility, wide substrate scope, providing transition-metal- oxidant-free pathway to access seven-membered rings under mild reaction conditions. Additionally, further transformation benzazepines large-scale experiment were also conducted.
Язык: Английский
Процитировано
12Organic Letters, Год журнала: 2022, Номер 24(50), С. 9243 - 9247
Опубликована: Дек. 14, 2022
A number of γ-cyanoalkyl radicals were generated by sustainable N-heterocyclic carbene catalysis in tin-, transition-meal-, and light-free conditions, followed insertion into biaryl isonitriles, thus leading to the rapid assembly a variety diversely functionalized 6-cyanoalkyl phenanthridines. preliminary mechanism study revealed that single-electron transfer radical process was possibly involved.
Язык: Английский
Процитировано
17ChemistryOpen, Год журнала: 2024, Номер unknown
Опубликована: Июль 11, 2024
Abstract This review introduces the synthetic organic chemical value of α‐bromocarbonyl compounds with tertiary carbons. compound a carbon has been used primarily only as radical initiator in atom transfer polymerization (ATRP) reactions. However, recent development photo‐radical reactions (around 2010), research on use alkyl precursors became popular 2012). As more examples were reported, studied not radicals but also for their applications organometallic and ionic That is, act nucleophiles well electrophiles. The carbonyl group is attractive because it allows skeleton to be converted after reaction, being applied total synthesis. In our survey until 2022, can perform full range necessary synthesis, including multi‐component reactions, cross‐coupling, substitution, cyclization, rearrangement, stereospecific asymmetric α‐Bromocarbonyl have created new trend alkylation, which then had limited reaction patterns focuses how chemistry.
Язык: Английский
Процитировано
4Chemistry - An Asian Journal, Год журнала: 2023, Номер 18(8)
Опубликована: Фев. 28, 2023
Abstract A mild and versatile cerium‐mediated decarboxylative strategy for sequential alkylation/cyclization was developed the synthesis of quaternary oxindoles benzimidazo[2,1‐ a ]isoquinolin‐6(5 H )‐ones via photoinduced‐LMCT. This operationally simple procedure relies on inexpensive feedstock carboxylic acids as alkyl radical surrogates aerial molecular oxygen terminal oxidant. atom economical protocol showed viability with wide range (1° to 3° acids) coupling partners also allows late‐stage modification pharmaceutically‐important acids. Mechanistic studies revealed reaction follow pathway, while event studied by in situ FTIR.
Язык: Английский
Процитировано
9Tetrahedron Chem, Год журнала: 2025, Номер unknown, С. 100124 - 100124
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0Synthetic Communications, Год журнала: 2025, Номер unknown, С. 1 - 9
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
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