Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Chiral
2-azetines
and
allenes
are
highly
valuable
structural
units
in
natural
products
useful
chemicals.
However,
enantioselective
synthesis
of
both
has
been
extremely
challenging.
Herein,
we
present
asymmetric
construction
chiral
(70-98
%
yields
up
to
96
ee)
through
phosphine-catalyzed
[2+2]
annulation
yne-enones
with
sulfamate-derived
cyclic
imines.
These
were
easily
transformed
into
upon
treatment
Et
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(12), С. 7774 - 7783
Опубликована: Апрель 12, 2023
We
have
developed
a
chiral
phosphoric
acid-catalyzed
enantioselective
Friedel-Crafts
alkylation
reaction
between
pyrroles
and
indolylmethanols.
Wide
substrate
scope
was
observed,
all-carbon
quaternary
center
constructed
at
the
3
position
of
indoles
in
high
yields
with
to
excellent
enantioselectivities
(up
99%
ee).
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(46)
Опубликована: Май 6, 2024
The
chemical
space
of
chiral
Brønsted
acid
catalysts
is
defined
by
quantity
and
complexity,
reflecting
the
diverse
synthetic
challenges
confronted
innovative
molecular
designs
introduced.
Here,
we
detail
how
this
successful
outcome
a
powerful
demonstration
benefits
utilizing
both
local
structure
searches
comprehensive
understanding
catalyst
performance
for
effective
efficient
exploration
properties.
In
concept
article
provide
an
evolutionary
overview
field
summarizing
approaches
to
optimization,
resulting
structures,
functions.
ACS Omega,
Год журнала:
2024,
Номер
9(31), С. 33351 - 33364
Опубликована: Июль 26, 2024
Chiral
allenes
and
styrenes
are
essential
components
in
fields
like
medicinal
chemistry,
materials
science,
organic
synthesis.
They
serve
a
crucial
role
as
chiral
ligands
catalysts
asymmetric
Over
the
past
decade,
there
has
been
significant
advancement
development
of
practical
methods
utilizing
organocatalytic
strategies
for
synthesis
styrenes.
It
is
noteworthy
that
despite
extensive
studies
on
formation
styrenes,
existing
reviews
their
construction
confined
to
specific
organocatalysis,
called
phosphoric
acid
catalysis,
less
documented.
This
review
aims
explore
different
conceptual
approaches
based
electrophilic
species
involved
reaction
produce
stereoselective
providing
insights
into
recent
advancements
field.
Emphasis
placed
works
published
since
2017,
with
detailed
discussions
mechanisms
examples
from
literature.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Chiral
2-azetines
and
allenes
are
highly
valuable
structural
units
in
natural
products
useful
chemicals.
However,
enantioselective
synthesis
of
both
has
been
extremely
challenging.
Herein,
we
present
asymmetric
construction
chiral
(70-98
%
yields
up
to
96
ee)
through
phosphine-catalyzed
[2+2]
annulation
yne-enones
with
sulfamate-derived
cyclic
imines.
These
were
easily
transformed
into
upon
treatment
Et
