ACS Omega, Год журнала: 2024, Номер 9(50), С. 49071 - 49080
Опубликована: Дек. 5, 2024
Formaldehyde has been used as a solvent and source of carbon to insert methylene group for bridging two imidazo[1,5-
Язык: Английский
Topics in Current Chemistry, Год журнала: 2024, Номер 382(1)
Опубликована: Фев. 25, 2024
Язык: Английский
Процитировано
13
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(5), С. 1044 - 1058
Опубликована: Янв. 12, 2024
Abstract This review centers on the synthetic strategies employed with indolyl‐ynones. Indolyl‐ynone, owing to its highly reactive ynone moiety, frequently partakes in dearomatizing spirocyclization reactions and subsequent rearrangement when subjected various reaction conditions. Hence, heterocycles such as densely functionalized spiroindolenines, carbazoles, quinolines carbo‐and hetero‐cycle substituted indoles are synthesized from In addition this, versatile spirocyclic indole scaffold exhibits capability produce tetracyclic polyclic structures through intricate skeletal processes. Moreover, total synthesis of natural products using indolyl‐ynone moiety was also compiled this review.
Язык: Английский
Процитировано
5
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8620 - 8631
Опубликована: Май 29, 2024
The short and first total synthesis of (+)-colletotryptins B-D, ent-colletotryptin A, diastereomer mucronatin B, which are a group natural 3-(indol-2-yl)-3-(indol-3-yl)-1,2-propanediol (IIPDO) analogues containing two stereogenic centers at the C8′ C9′ positions, isolated from endophytic fungus Colletotrichum sp. SC1355 Tetrapterys mucronata, respectively, has been successfully accomplished in three steps with overall yields ranging 28 to 54%. Key features this include an innovative Bi(OTf)3-catalyzed stereoselective transindolylation (S)-3,3′-di(1H-indol-3-yl)propane-1,2-diol. operational simplicity, environmentally friendly catalyst, broad functional tolerance modular strategy render it suitable for adoption both academic industrial settings.
Язык: Английский
Процитировано
5
Molecular Catalysis, Год журнала: 2023, Номер 547, С. 113285 - 113285
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
11
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(4), С. 2377 - 2384
Опубликована: Фев. 2, 2023
A general electrophilic iodocyclization/nucleophile addition cascade transformation for 1,2-alkynediones the synthesis of various oxygen heterocycles and access to regioselective alkyne hydroxylation is reported. Furan-tethered ynediones resulted in construction exo-enol ethers via carbonyl-alkyne cyclization-initiated heteroarene dearomatization, whereas other (hetero)arene-, alkenyl-, alkyl-tethered formation highly functionalized 3(2H)-furanones. Importantly, developed domino protocols involve important heterocyclic scaffolds installation two functional groups a single operation. Moreover, use water as nucleophile furanone ring opening. The are characterized by wide substrate scope, their utility has been demonstrated number postsynthetic transformations.
Язык: Английский
Процитировано
10
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11665 - 11670
Опубликована: Авг. 6, 2024
Herein we disclose a transition-metal-free, one-pot two-step strategy for the synthesis of unsymmetrical bis-heteroaryl ketones.
Язык: Английский
Процитировано
3
Chemical Communications, Год журнала: 2023, Номер 59(84), С. 12649 - 12652
Опубликована: Янв. 1, 2023
Ag( i )-catalyzed highly diastereoselective construction of divergent spiroindolines via dearomatizing indole-ynone spirocyclization/nucleophile addition cascade reaction is disclosed herein.
Язык: Английский
Процитировано
6
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(7), С. 4052 - 4065
Опубликована: Март 7, 2023
This paper reports the acid-controlled divergent synthesis of 3-pyrrolidin-2-yl-1H-indoles and symmetric unsymmetrical bis(indolyl)methanes (BIMs) through photocatalyzed decarboxylative coupling Friedel-Crafts alkylation reactions, respectively. The protocol involves C-H functionalization, switching formation two products, room-temperature conditions, low photocatalyst loadings, without strong oxidant, moderate to excellent yields. method has been applied for natural product vibrindole A 1,1-bis(1H-indol-3-yl)-2-phenylethane.
Язык: Английский
Процитировано
5
Organic Letters, Год журнала: 2024, Номер 26(28), С. 5995 - 6000
Опубликована: Июль 11, 2024
Enantioselective synthesis of 3(2H)-furanones has been achieved using the intermolecular H-bonding activation gold(I) chloride complexes. A DM-BINAP [(R)-(+)-2,2′-Bis[di(3,5-xylyl)phoshino]-1,1′-binaphthyl] digold(I) dichloride complex in combination with a sulfonyl squaramide (SO2Sq) identified as optimal catalytic system. The process involves 5-endo-dig oxa-cyclization followed by stereocontrolled addition indoles. Interestingly, soft L*Au–Cl allowed recovery both and activator after chromatographic purification.
Язык: Английский
Процитировано
1
DELETED, Год журнала: 2022, Номер 88(4), С. 501 - 527
Опубликована: Сен. 5, 2022
Gold catalysis has emerged as an important tool in the field of synthetic organic chemistry for selective functionalization C–C multiple bonds. The research India on gold focuses diverse fields starting from methodology developments to synthesis molecular scaffolds their potential application medicinal and material science. Herein, we present a comprehensive overview gold-catalyzed transformations that were reported last fifteen years.
Язык: Английский
Процитировано
3