Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
A
cascade
phosphorylation
cycloisomerization
of
readily
accessible
ynones
and
diphenylphosphine
oxides
facilitated
by
potassium
phosphate
is
described,
allowing
for
the
straightforward
synthesis
C4‐phosphorylated
quinoline
scaffolds.
The
formation
a
C−P
bond
C−N
achieved
in
single
procedure
without
need
pre‐assembled
cores
prior
to
phosphorylation.
This
transformation
operates
requirement
metals
or
oxidants
exhibits
excellent
compatibility
with
various
functional
groups.
Furthermore,
antimicrobial
activity
evaluation
demonstrated
that
synthesized
derivatives
exhibited
potent
inhibitory
against
Staphylococcus
aureus.
Organic Letters,
Год журнала:
2023,
Номер
25(44), С. 8016 - 8021
Опубликована: Окт. 30, 2023
Direct,
economical,
and
green
synthesis
of
deuterated
α-amino
phosphine
oxides
remains
an
elusive
challenge
in
synthetic
chemistry.
Herein,
we
report
a
visible-light-driven
umpolung
strategy
for
synthesizing
from
isocyanide
using
1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene
as
the
photocatalyst
D2O
deuterium
source.
Moreover,
streamlined
sustainable
methodology
can
be
applied
modification
amino
acids,
natural
products,
drugs.
The
strong
antiproliferative
activity
desired
products
indicates
that
method
could
provide
novel
privileged
scaffold
antitumor
drug
development.
Chemical Reviews,
Год журнала:
2024,
Номер
124(12), С. 7907 - 7975
Опубликована: Май 29, 2024
The
increasing
importance
of
azaheterocyclic
phosphonates
in
the
agrochemical,
synthetic,
and
medicinal
field
has
provoked
an
intense
search
development
synthetic
routes
for
obtaining
novel
members
this
family
compounds.
This
updated
review
covers
methodologies
established
since
2004,
focusing
on
synthesis
phosphonates,
which
phosphonate
moiety
is
directly
substituted
onto
to
structure.
Emphasizing
recent
advances,
classifies
newly
developed
approaches
according
ring
size
providing
information
biological
activities
whenever
available.
Furthermore,
summarizes
various
methods
formation
C–P
bonds,
examining
sustainable
such
as
Michaelis–Arbuzov
reaction,
Michaelis–Becker
Pudovik
Hirao
coupling,
Kabachnik–Fields
reaction.
After
analyzing
applications
investigated
years,
a
predominant
focus
evaluation
these
compounds
anticancer
agents
evident.
emerging
underline
versatility
potential
compounds,
highlighting
need
continued
research
expand
interesting
family.
Organic Letters,
Год журнала:
2024,
Номер
26(7), С. 1393 - 1398
Опубликована: Фев. 12, 2024
We
disclose
herein
a
photocatalytic
radical
cascade
cyclization
of
diazoalkanes
for
the
divergent
synthesis
important
carbocycles
and
heterocycles.
Under
optimal
reaction
conditions,
various
indanone,
pyrone,
pyridinone
derivatives
can
be
obtained
in
moderate
to
good
yields.
Mechanistic
experiments
support
formation
carbon-centered
radicals
from
through
proton-coupled
electron
transfer
process.
Scale-up
using
continuous
flow
technology
useful
downstream
application
formed
heterocycles
further
render
strategy
attractive
valuable.
Organic Letters,
Год журнала:
2024,
Номер
26(22), С. 4727 - 4732
Опубликована: Май 29, 2024
A
visible-light-induced
photocatalyst-free
acylative
pyridylation
of
styrenes
with
4-acyl-1,4-dihydropyridines
(DHPs)
and
4-cyanopyridines
has
been
described,
featuring
mild
reaction
conditions,
a
broad
substrate
scope,
good
functional
group
tolerance.
The
could
also
be
performed
under
sunlight
irradiation
albeit
slightly
lower
conversion.
4-Acyl-1,4-DHPs
serve
dual
role,
acting
as
both
photoreductant
to
reduce
the
cyanopyridine
its
radical
anion
intermediate
precursor
produce
acyl
radical.
mechanism
was
especially
elucidated
through
Hammett
analysis,
quadratic
linear
regression
analysis
by
using
parameters,
σmb
σjj·.
findings
from
further
demonstrate
that
rate-limiting
step
process
is
single
electron
transfer
between
4-acyl-1,4-DHPs
4-cyanopyridines.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(4), С. 635 - 697
Опубликована: Янв. 13, 2024
Abstract
In
recent
years,
the
interest
to
develop
cyclizations
promoted
by
visible
light
has
been
gaining
a
lot
of
attention
due
its
sustainability
aspect.
this
review,
we
summarize
most
important
advances
in
period
describing
methods
used
generate
different
ring
sizes,
while
focusing
on
mechanistic
details
these
reactions.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(5), С. 2996 - 3009
Опубликована: Фев. 15, 2024
An
efficient
and
highly
regioselective
C6-phosphorylation
protocol
for
pyrrolo[2,3-d]pyrimidine
(7-DAP)
derivatives
with
various
H-phosphine
oxides
induced
by
visible
light
at
room
temperature
is
described
the
first
time.
This
has
been
successfully
achieved
combination
of
Na2-eosin
Y
as
a
photocatalyst
LPO
an
oxidant
under
transition
metal-
additive-free
conditions.
The
broad
substrate
scope,
good
functional
group
tolerance,
excellent
regioselectivity,
air
tolerant
conditions
make
this
process
favorable
modification
scaffold
enrich
phosphorylated
7-DAP
compounds
further
biological
evaluation.
Chemical Science,
Год журнала:
2024,
Номер
15(19), С. 7136 - 7143
Опубликована: Янв. 1, 2024
Herein,
we
have
developed
efficient
radical
phosphonylations
tailored
upon
visible-light
mediated
LMCT
on
bismuth.
Phosphonylation
of
a
broad
range
substrate
classes
was
carried
out
under
mild
energy
conditions
using
BiCl
3
as
the
catalyst.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Авг. 12, 2023
Abstract
Utilizing
the
Knoevenagel–Michael
tandem
cyclocondensation
reaction
of
barbituric
acid/1,3-dimethylbarbituric
acid,
malononitrile,
and
aryl
aldehydes,
a
sustainable
methodology
for
photosynthesis
pyrano[2,3-
d
]pyrimidine
scaffolds
has
been
devised.
The
present
study
expounds
on
development
green
radical
synthetic
approach
toward
this
class
compounds.
In
study,
novel
halogenated
dicyanobenzene-based
photosensitizer
was
utilized
in
an
aqueous
solution,
exposed
to
air
at
room
temperature,
activated
by
blue
LED
as
renewable
energy
source
purpose
generating
energy.
primary
aim
endeavor
is
employ
recently
developed,
easily
obtainable,
affordably
priced
cyanoarene-based
donor–acceptor
(D–A).
3DPAFIPN
[2,4,6-tris(diphenylamino)-5-fluoroisophthalonitrile]}
photocatalyst,
thermally
delayed
fluorescence
(TADF),
capable
inducing
single
electron
transfer
(SET)
upon
irradiation
with
visible
light,
thereby
offering
facile
efficient
high
degree
effectiveness,
efficiency,
eco-friendliness.
aforementioned
phenomenon
facilitates
exploration
temporal
changes
that
have
occurred
interactions
between
surroundings
chemical
constituents.
aimed
investigate
turnover
number
(TON)
frequency
(TOF)
scaffolds.
Additionally,
it
demonstrated
gram-scale
cyclization
viable
method
utilization
industrial
applications.
Organic Letters,
Год журнала:
2024,
Номер
26(18), С. 3810 - 3815
Опубликована: Апрель 28, 2024
A
visible-light-driven
photocatalytic
protocol
is
established
for
the
diastereoselective
synthesis
of
pyrrolo[3,2,1-jk]carbazoles
via
a
radical-triggered
multicomponent
bicyclization
reaction
starting
from
readily
available
indole-tethered
1,6-enynes
and
α-benzyl-α-bromomalonates
under
mild
conditions.
This
approach
exhibits
wide
substrate
compatibility
excellent
tolerability
toward
various
functional
groups
boasts
benefit
efficient
ring
formation
chemical
bond
creation.
