Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
A
cascade
phosphorylation
cycloisomerization
of
readily
accessible
ynones
and
diphenylphosphine
oxides
facilitated
by
potassium
phosphate
is
described,
allowing
for
the
straightforward
synthesis
C4‐phosphorylated
quinoline
scaffolds.
The
formation
a
C−P
bond
C−N
achieved
in
single
procedure
without
need
pre‐assembled
cores
prior
to
phosphorylation.
This
transformation
operates
requirement
metals
or
oxidants
exhibits
excellent
compatibility
with
various
functional
groups.
Furthermore,
antimicrobial
activity
evaluation
demonstrated
that
synthesized
derivatives
exhibited
potent
inhibitory
against
Staphylococcus
aureus.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
30(10)
Опубликована: Ноя. 29, 2023
Abstract
A
new
protocol
by
the
combinatory
use
of
two
equivalent
indazoles
starting
material
with
one
being
carbon
source
via
its
C3‐reactivity
and
other,
coupling
partner
has
been
developed
for
selectfluor‐mediated
single
atom
skeletal
editing
2
H
‐indazoles.
The
azo‐linked‐2,3‐disubstituted
quinazolin‐4‐one
derivatives
were
obtained
through
a
insertion
between
nitrogens
indazole
ring
simultaneous
oxidation
at
C3
position
both
moieties.
Mechanistic
investigations
reveal
that
amidic
carbonyl
oxygen
product
is
derived
from
water
reaction
proceeds
in‐situ
generated
N
‐centred
indazolone
radical
intermediate.
Chemical Communications,
Год журнала:
2024,
Номер
60(62), С. 8119 - 8122
Опубликована: Янв. 1, 2024
A
novel
visible-light
promoted
metal-free
radical
cascade
cyclization
reaction
has
been
developed
with
3-allyl-2-arylquinazolinones
as
a
new
class
of
acceptor.
This
photocatalytic
protocol
represents
an
efficient
approach
to
construct
phosphorylated
dihydroisoquinolino[1,2-
ACS Sustainable Chemistry & Engineering,
Год журнала:
2023,
Номер
11(37), С. 13798 - 13804
Опубликована: Сен. 1, 2023
A
process
for
the
electrochemical
direct
C–H
arylation
of
quinazolinones
and
aryl
tetrafluoroborate
diazonium
salts
with
ionic
liquid
[EMIM]BF4
(1-ethyl-3-methylimidazolium
tetrafluoroborate):H2O
(2:1)
as
electrolyte
was
developed
synthesis
2-arylquinazolinones,
a
series
2-arylquinazolinones
were
synthesized
moderate
to
good
yields.
This
method
applied
key
intermediate
an
IKK
β
inhibitor
CU160
quinazolinone
alkaloid
2-(1H-indol-3-yl)
quinazolin-4(3H)-one.
The
mild
green
scheme
provides
effective
alternative
traditional
2-arylquinazolinone.
Current Organic Chemistry,
Год журнала:
2023,
Номер
27(12), С. 997 - 1009
Опубликована: Июнь 1, 2023
Abstract:
Nitrogen
ring
junction
heterocycles
play
a
crucial
role
in
synthetic
organic
chemistry
due
to
their
remarkable
activity.
The
fused
nitrogen
compounds
are
abundant
nature;
they
have
excellent
biological
activity
and
used
against
various
health
issues.
To
make
selective
products
from
the
heterocycles,
expensive
chemicals
catalysts,
like
transition
metal
complexes
composites,
required.
neglect
drawbacks
of
conventional
synthesis
methods
long
reaction
times,
by-product
formation,
lower
selectivity,
low
yields,
an
alternative
nonconventional
light-mediated
techniques
can
be
opted
for.
light
source
uses
radical
mechanism
that
reduces
provides
regio-selective
product,
increases
yield,
decreases
time,
is
cost-effective,
does
not
require
special
catalysts
or
chemicals.
There
variety
sources,
viz.,
UV,
visible,
IR,
laser,
X-ray.
visible
light,
white,
green,
blue
LED
sources
widely
photochemical
method.
This
review
emphasizes
nitrogen-ring
heterocyclic
compounds.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
A
cascade
phosphorylation
cycloisomerization
of
readily
accessible
ynones
and
diphenylphosphine
oxides
facilitated
by
potassium
phosphate
is
described,
allowing
for
the
straightforward
synthesis
C4‐phosphorylated
quinoline
scaffolds.
The
formation
a
C−P
bond
C−N
achieved
in
single
procedure
without
need
pre‐assembled
cores
prior
to
phosphorylation.
This
transformation
operates
requirement
metals
or
oxidants
exhibits
excellent
compatibility
with
various
functional
groups.
Furthermore,
antimicrobial
activity
evaluation
demonstrated
that
synthesized
derivatives
exhibited
potent
inhibitory
against
Staphylococcus
aureus.
