Multi-Hydroxyl POSS Supported Iridium Complexes as a Recyclable Catalyst for Selective Synthesis of N-/C-Substituted Indoles and the Total Synthesis of HIV-1 Fusion Inhibitor DOI
Jiahao Li, Li Chen, Likui Wang

и другие.

Опубликована: Янв. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Язык: Английский

Unveiling the Potential of SNS-Ni Complex for Establishing C–N Bonds: An Approach toward Chemoselectivity DOI
Rahul Sharma, Avijit Mondal, Suman Maji

и другие.

Organometallics, Год журнала: 2024, Номер 43(21), С. 2697 - 2702

Опубликована: Окт. 7, 2024

Recent research has focused a lot on using the borrowing hydrogen (BH) approach to react amines with alcohols convert C–O bond into C–N bond. However, notion of chemoselectivity in BH-mediated N-alkylation rarely been studied. Herein, we have demonstrated application synthesized SNS-Ni complex constructing various bonds via coupling diverse alcohols. Delightfully, catalytic protocol also activates challenging C4–C16 aliphatic Aryl amino are selectively N-alkylated different alcohols, while keeping OH group intact alcohol portion. Furthermore, without reducing distal unsaturation, technique was successfully employed for chemoselective fatty The preliminary mechanistic investigation suggests alkylation occurs nonradical pathway.

Язык: Английский

Процитировано

0
Nickel-Catalyzed One-Pot Cascade Synthesis of N‑Substituted Indoles DOI
Mark A. Reed, Prashant S. Deore

Synfacts, Год журнала: 2023, Номер 19(04), С. 0342 - 0342

Опубликована: Март 17, 2023

Key words nickel catalysis - cascade synthesis N‑substituted indoles hydrogen autotransfer

Язык: Английский

Процитировано

0
Multi-Hydroxyl POSS Supported Iridium Complexes as a Recyclable Catalyst for Selective Synthesis of N-/C-Substituted Indoles and the Total Synthesis of HIV-1 Fusion Inhibitor DOI
Jiahao Li, Li Chen, Likui Wang

и другие.

Опубликована: Янв. 1, 2023

A novel pyridyl-thiadiazole ligand has been designed, synthesized, and employed in the preparation of a heterogeneous iridium catalyst supported on multi-hydroxyl polyhedral oligomeric silsesquioxane. The as-prepared exhibits excellent catalytic activity one-pot cascade selective synthesis N-/C-substituted indole derivatives from amino alcohols via borrowing hydrogen strategy. Meanwhile, it was observed that this approach good functional group tolerance broad substrate scope. Notably, by employing system, an inhibitor against gp41-mediated HIV-1 fusion core structure could be conveniently synthesized 2-aminophenethyl alcohol benzyl 40.6% total yield for only four steps “borrowing hydrogen” Mechanistic explorations showed transformation undergoes processes, involving N/C-alkylation through strategy, oxidative cyclization. Recycling experiments disclosed easily recovered reused at least seven times with TON.

Язык: Английский

Процитировано

0