Synthesis,
Год журнала:
2023,
Номер
56(01), С. 179 - 186
Опубликована: Окт. 18, 2023
Abstract
An
efficient
and
environment-friendly
synthesis
of
aryl
carboxylic
acids
through
the
ambient
electro-oxidation
arylacetylenes
is
demonstrated.
The
reaction
proceeds
smoothly
at
certain
applied
potentials
in
a
mixed
solution
acetonitrile
water
with
potassium
peroxymonosulfate
(Oxone)
as
additive.
isolated
yields
desired
products
are
good
up
to
90%,
exhibits
excellent
functional-group
tolerance.
In
this
electrochemical
system,
transition
metal
catalysts,
extra
acids/bases,
high
temperature
not
required.
This
method
may
open
pathway
for
by
electrochemistry
strategy.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(10), С. 2762 - 2767
Опубликована: Янв. 1, 2024
A
P(NMe2)3-catalyzed
[4
+
2]
annulation
of
2-amino-β-nitrostyrenes
and
β′-acetoxy
allenoates
followed
by
a
Zn/AcOH-mediated
reduction–hydroamination–isomerization
has
been
developed.
Organic Letters,
Год журнала:
2023,
Номер
25(33), С. 6143 - 6148
Опубликована: Авг. 16, 2023
Herein,
we
have
successfully
developed
a
convergent
paired
electrolysis
strategy
for
the
defluorinative
thiolation
process
utilizing
thiols
and
gem-difluoroalkenes
as
precursors.
This
protocol
exhibits
remarkable
tolerance
toward
wide
range
of
functional
groups,
exemplified
by
successful
late-stage
defluorothiolation
complex
molecules.
Additionally,
this
is
amenable
to
gram-scale
synthesis,
making
use
both
anodic
oxidation
cathodic
reduction
processes
in
an
efficient
manner.
Several
control
studies
were
conducted
suggested
mechanism.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
An
efficient
metal-free
approach
for
synthesizing
N-aryl-
and
N-alkyl
phthalimide
derivatives
from
1,2,3-benzotriazin-4(3H)-ones
is
described.
The
reaction
likely
proceeds
via
a
denitrogenative
cyanation
pathway,
utilizing
TMSCN
as
the
cyanide
source.
This
method
straightforward
well
scalable
supports
wide
range
of
substrates
with
high
functional
group
tolerance,
yielding
diverse
in
good
to
excellent
yields.
utility
this
further
highlighted
by
successful
synthesis
tyrosinase
inhibitor
analogue
yield.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 23, 2024
Abstract
Low‐energy
light,
endowing
with
excellent
characteristics
of
lower
energy,
fewer
side
reactions,
more
abundance
in
solar
light.
The
scenario
has
been
developed
for
the
fabrication
indenone
through
a
low‐energy
green
light
driven
radical
annulation
reaction
between
α‐keto
acids
and
internal
alkynes
using
Rhodamine
6G
as
photocatalyst.
Various
kinds
substrates
are
suitable
this
methodology,
affording
corresponding
indenones
greener
efficient
manner.
Organic Letters,
Год журнала:
2024,
Номер
26(36), С. 7576 - 7583
Опубликована: Сен. 3, 2024
An
efficient
pyridine-catalyzed
chemoselective
four-component
cascade
reaction
of
aromatic
aldehydes,
malononitrile/cyanoacetates,
Morita-Baylis-Hillman
(MBH)
carbonates,
and
alcohols
has
been
established.
This
one-pot
progressed
in
an
unusual
with
solvent
participation
via
a
Knoevenagel
condensation/oxa-Michael
addition/S
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(35)
Опубликована: Апрель 18, 2024
Utilizing
periodic
acid
as
an
environmentally
benign
oxidizing
agent,
this
study
introduces
a
novel
mechanochemical
method
that
mimics
ozonolysis
to
convert
internal
alkynes
into
1,2-diketones,
showcasing
effective
emulation
of
ozone's
reactivity.
Notably,
oxidation
occurs
at
room
temperature
in
aerobic
conditions,
eliminating
the
need
for
toxic
transition
metals,
hazardous
oxidants,
or
expensive
solvents.
Through
control
experiments
validating
mechanism,
substantial
evidence
supports
concerted
reaction
pathway.
This
progress
marks
significant
stride
toward
cleaner
and
more
efficient
chemical
synthesis,
mitigating
environmental
impact
conventional
processes.
Assessing
green
chemistry
metrics
both
solvent-free
previously
reported
solvent-based
methods,
our
eco-friendly
protocol
demonstrates
E-factor
7.40,
51.7
%
atom
economy,
45.5
efficiency,
100
carbon
11.9
mass
efficiency
when
solvents
are
not
used.
Abstract
Selective
oxidation
is
one
of
the
primary
methods
used
to
synthesize
high‐value‐added
oxygen‐containing
organic
compounds
from
alkenes.
In
particular,
selective
natural
cinnamaldehyde
has
gained
prominence
as
main
routes
produce
benzaldehyde,
which
in
short
supply
global
spice
market.
this
study,
FeSBA
catalysts
were
synthesized
by
supporting
Fe
2
O
3
onto
surface
spherical
SBA‐15
using
pore‐induced
deposition
for
benzaldehyde.
The
increased
specific
area
approximately
eightfold
and
significantly
improved
utilization
efficiency
reaction
sites
on
.
Additionally,
formation
Fe−O−Si
bonds
promoted
generation
weak‐acidic
catalyst
surface,
increasing
oxygen‐physisorption
capacity
Furthermore,
quenching
experiments
confirmed
significant
amounts
O2
−
singlet‐oxygen
species
surface.
Theoretical
calculations
that
physisorption
chemisorption
oxygen,
respectively,
a
tetrameric
intermediate.
These
results
contribute
research
theory
α,β‐unsaturated
aldehydes
oxygen
could
guide
future
studies
aimed
at
elucidating
improving
process.
iScience,
Год журнала:
2023,
Номер
26(9), С. 107608 - 107608
Опубликована: Авг. 12, 2023
An
unprecedented
efficient
protocol
is
developed
for
the
oxidative
cleavage
of
C≡C
bonds
in
alkynes
to
produce
structure-diverse
esters
using
heterogeneous
cobalt
nanoparticles
as
catalyst
with
molecular
oxygen
oxidant.
A
diverse
set
mono-
and
multisubstituted
aromatic
aliphatic
can
be
effectively
cleaved
converted
into
corresponding
esters.
Characterization
analysis
control
experiments
indicate
high
surface
area
pore
volume,
well
nanostructured
nitrogen-doped
graphene-layer
coated
are
possibly
responsible
excellent
catalytic
activity.
Mechanistic
studies
reveal
that
ketones
derived
from
under
conditions
formed
intermediates,
which
subsequently
through
a
tandem
sequential
process.
The
recycled
up
five
times
without
significant
loss
