Digoxin and its Na+/K+-ATPase-targeted actions on cardiovascular diseases and cancer
Yulin Ren,
Andrew T. Anderson,
Gunnar Meyer
и другие.
Bioorganic & Medicinal Chemistry,
Год журнала:
2024,
Номер
114, С. 117939 - 117939
Опубликована: Окт. 5, 2024
Язык: Английский
Synthesis of Bufadienolide Cinobufagin via Late-Stage Singlet Oxygen Oxidation/Rearrangement Approach
Organic Letters,
Год журнала:
2024,
Номер
26(12), С. 2445 - 2450
Опубликована: Март 15, 2024
This
manuscript
describes
a
concise
synthesis
of
cinobufagin,
natural
steroid
the
bufadienolide
family,
from
readily
available
dehydroepiandrosterone
(DHEA),
as
well
its
α5-epimer
derived
3-
Язык: Английский
Recent Advances in Organic Photocatalyst‐Promoted Carbohydrate Synthesis and Modification under Light Irradiation
Chemistry - An Asian Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Abstract
Photoredox
catalysis
has
been
developed
as
a
sustainable
and
eco‐friendly
catalytic
strategy,
which
might
provide
innovative
solutions
to
solve
the
current
synthetic
challenges
barriers
in
carbohydrate
chemistry.
During
last
few
decades,
study
of
organic
photocatalyst‐promoted
synthesis
modification
received
significant
attention,
provides
an
excellent
inexpensive
metal‐free
alternative
photoredox
well
introduces
new
fastest‐growing
era
access
complex
carbohydrates
simply.
In
this
review,
we
aim
overview
under
light
irradiation,
is
expected
directions
for
further
investigation.
Язык: Английский
The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
Cellular and Molecular Life Sciences,
Год журнала:
2023,
Номер
80(9)
Опубликована: Авг. 16, 2023
Abstract
Cardiac
glycosides
(CGs)
are
a
class
of
bioactive
organic
compounds
well-known
for
their
application
in
treating
heart
disease
despite
narrow
therapeutic
window.
Considerable
evidence
has
demonstrated
the
potential
to
repurpose
CGs
cancer
treatment.
Chemical
modification
these
been
utilized
attempts
increase
anti-cancer
properties;
however,
this
met
limited
success
as
mechanism
action
is
still
speculative.
Recent
studies
have
identified
DNA
damage
response
(DDR)
pathway
target
CGs.
DDR
serves
coordinate
numerous
cellular
pathways
initiate
cell
cycle
arrest,
promote
repair,
regulate
replication
fork
firing
and
protection,
or
induce
apoptosis
avoid
survival
cells
with
carrying
mutations.
Understanding
modus
operandi
cardiac
will
provide
critical
information
better
address
improvements
potency,
reduced
toxicity,
overcome
drug
resistance.
This
review
summarizes
recent
scientific
findings
molecular
mechanisms
affecting
signaling
therapeutics
from
2010
2022.
We
focus
on
structural
functional
differences
toward
identifying
features
targeting
agents.
Язык: Английский
Selective (α)-l-Rhamnosylation and Neuroprotective Activity Exploration of Cardiotonic Steroids
ACS Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
15(2), С. 280 - 286
Опубликована: Янв. 8, 2024
This
work
describes
the
studies
on
direct
C3-glycosylation
of
C19-hydroxylated
cardiotonic
steroids
strophanthidol,
anhydro-ouabagenin,
and
ouabagenin
using
a
strategy
based
in
situ
protection
C5
C19
hydroxyl
groups
with
boronic
acids.
While
this
resulted
successful
one-pot
C3-selective
glycosylation
strophanthidol
anhydro-ouabegenin,
it
failed
to
provide
ouabain
from
ouabagenin.
The
neuroprotective
activity
synthetic
natural
glycosides
against
LPS-induced
neuroinflammation
was
explored
neonatal
mouse
primary
glia
cells.
Co-administration
C3-glycosides
at
200
nM
concentrations
significant
reduction
neuroinflammatory
markers
IL-6,
IL-1,
TNFα,
IKBKE,
anhydro-ouabagenin-3-(α)-l-rhamnoside
(anhydro-ouabain)
showing
most
effect.
At
same
time,
unglycosylated
anhydro-ouabagenin
enhanced
rather
than
suppressed
neuroinflammation.
Язык: Английский
A New Bioactive Cardenolide from Nerium oleander
Revista Brasileira de Farmacognosia,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Язык: Английский
Origins of Selectivity in Glycosylation Reactions with Saccharosamine Donors
Organic Letters,
Год журнала:
2023,
Номер
25(49), С. 8856 - 8860
Опубликована: Дек. 7, 2023
A
combination
of
DFT
calculations
and
experiments
is
used
to
describe
how
the
selection
a
promoter
can
control
stereochemical
outcome
glycosylation
reactions
with
deoxy
sugar
saccharosamine.
Depending
on
promoter,
either
α-
or
β-linked
reactive
intermediates
are
formed.
These
studies
show
that
differential
modes
activation
lead
formation
distinct
undergo
highly
selective
through
an
SN2-like
mechanism.
Язык: Английский
Synthesis of Acovenosides: Cardiac Glycosides with Potent Antitumor Activities
Benzhang Liu,
Shuyang Bi,
Jing Wang
и другие.
Organic Letters,
Год журнала:
2024,
Номер
26(41), С. 8725 - 8729
Опубликована: Окт. 7, 2024
Acovenoside
A
(
Язык: Английский
Organometallic Photocatalyst‐Promoted Synthesis and Modification of Carbohydrates under Photoirradiation
The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Carbohydrates
are
natural,
renewable,
chemical
compounds
that
play
crucial
roles
in
biological
systems.
Thus,
efficient
and
stereoselective
glycosylation
is
an
urgent
task
for
the
preparation
of
pure
structurally
well-defined
carbohydrates.
Photoredox
catalysis
has
emerged
as
a
powerful
tool
carbohydrate
chemistry,
providing
alternative
addressing
some
challenges
glycochemistry.
Over
last
few
decades,
Ir-
Ru-based
organometallic
photocatalysts
have
attracted
significant
interest
because
their
high
stability,
high-energy
triplet
state,
strong
visible-light
absorption,
long
luminescence
lifetime,
amenability
to
ligand
modification.
This
review
highlights
recent
progress
photocatalyst-promoted
synthesis
modification
carbohydrates
under
photoirradiation,
well
related
benefits
drawbacks.
Язык: Английский