Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 27, 2024
Abstract
This
study
investigates
the
visible‐light‐initiated
uranyl(VI)‐catalyzed
activation
of
Si−H
bonds
through
direct
hydrogen
atom
transfer,
which
facilitates
formation
silyl
radicals
from
silanes.
The
radical
can
abstract
a
chlorine
sulfonyl
chloride,
leading
to
generation
radicals.
These
and
could
react
with
alkenes
alkynes,
achieving
first
example
uranyl‐catalyzed
hydrosilylation
hydrosulfonylation
unsaturated
C−C
bonds.
method
features
mild
reaction
conditions
broad
substrate
scope,
exhibits
exceptional
functional‐group
tolerance.
Consequently,
it
is
suitable
for
late‐stage
functionalization
drug
derivatives.
Organic Letters,
Год журнала:
2024,
Номер
26(5), С. 1011 - 1016
Опубликована: Янв. 30, 2024
A
novel
strategy
was
developed
to
generate
silyl
radicals
from
silylboronic
pinacol
esters
(SPEs)
through
nucleohomolytic
substitution
of
boron
with
aminyl
radicals.
We
successfully
applied
this
obtain
diverse
organosilicon
compounds
using
SPEs
and
N-nitrosamines
under
photoirradiation
without
any
catalyst.
The
ability
access
offers
a
new
perspective
for
chemists
rapidly
construct
Si–X
bonds.
Organic Letters,
Год журнала:
2025,
Номер
27(2), С. 680 - 685
Опубликована: Янв. 6, 2025
The
efficient
construction
of
chiral
aryl-containing
organosilicon
frameworks
via
catalytic
enantioselective
three-component
silylarylation
alkenes
remains
a
great
challenge.
Herein,
photoredox/nickel
dual-catalytic
asymmetric
protocol
has
been
disclosed
by
using
biimidazoline
(BiIM)
as
the
ligand,
silylboranes
silyl
radical
precursors,
aryl
bromides
coupling
partners,
and
morpholine
promoter.
Remarkably,
reaction
features
mild
green
conditions,
high
efficiency,
excellent
enantioselectivity,
enabling
facile
synthesis
valuable
tropic
acid
sila-isoflavanone
structures.
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Electron
donor–acceptor
complexes
are
commonly
employed
to
facilitate
photoinduced
radical-mediated
organic
reactions.
However,
achieving
these
photochemical
processes
with
catalytic
amounts
of
donors
or
acceptors
can
be
challenging,
especially
when
aiming
reduce
catalyst
loadings.
Herein,
we
have
unveiled
a
framework-based
heterogenization
approach
that
significantly
enhances
the
photoredox
activity
perylene
diimide
species
in
radical
addition
reactions
alkyl
silicates
by
promoting
faster
and
more
efficient
electron
complex
formation.
Besides
offering
broad
substrate
scope
alkene
hydroalkylation,
newly
developed
heterogeneous
photocatalysis
substantially
improves
turnover
numbers
comparison
previous
homogeneous
photocatalytic
systems
demonstrates
outstanding
recyclability.
These
research
findings
pave
way
for
advancement
various
practical
transformations
using
framework-supported
organocatalysts.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Heterogeneous
rhodium
catalysts
supported
on
phosphorus-rich
covalent
organic
polymers
provide
a
sustainable
solution
to
the
scarcity
of
Rh
resources
in
chemical
industry.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(45)
Опубликована: Июнь 3, 2023
The
hydrosilylation
of
alkenes
is
one
the
most
important
methods
for
synthesis
organosilicon
compounds.
In
addition
to
platinum-catalyzed
hydrosilylation,
silyl
radical
reactions
are
notable
as
economic
reactions.
An
efficient
and
widely
applicable
reaction
was
developed
by
using
2-silylated
dihydroquinazolinone
derivatives
under
photocatalytic
conditions.
Electron-deficient
styrene
underwent
give
products
in
good
high
yields.
Mechanistic
studies
indicated
that
photocatalyst
functioned
not
a
photoredox
catalyst
but
an
energy
transfer
catalyst.
DFT
calculations
clarified
triplet
excited
state
released
through
homolytic
cleavage
carbon-silicon
bond,
this
followed
hydrogen
atom
pathway,
redox
pathway.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4836 - 4842
Опубликована: Янв. 1, 2023
A
visible
light-induced
organophotocatalytic
strategy
for
synthesizing
functionalized
allylsilanes
through
radical
allylic
silylation
of
allyl
acetates
and
chlorides
is
reported.
ACS Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
15(2), С. 230 - 238
Опубликована: Янв. 5, 2024
Herein,
we
disclose
a
powerful
strategy
for
the
functionalization
of
antitumor
natural
alkaloid
noscapine
by
utilizing
photoredox/nickel
dual-catalytic
coupling
technology.
A
small
collection
37
new
noscapinoids
with
diverse
(hetero)alkyl
and
(hetero)cycloalkyl
groups
enhanced
sp3
character
was
thus
synthesized.
Further
in
vitro
antiproliferative
activity
screening
SAR
study
enabled
identification
6o
as
novel,
potent,
less-toxic
anticancer
agent.
Furthermore,
exerts
superior
cellular
via
an
unexpected
S-phase
arrest
mechanism
could
significantly
induce
cell
apoptosis
dose-dependent
manner,
thereby
further
highlighting
its
potential
drug
discovery
promising
lead
compound.
