Cobalt‐Catalyzed Hydrosilylation across Carbon‐Carbon, Carbon‐Oxygen, and Carbon‐Nitrogen Multiple Bonds – A Comprehensive Review

ChemCatChem, Год журнала: 2024, Номер 16(15)

Опубликована: Фев. 5, 2024

Abstract The selective conversion of unsaturated compounds has emerged as a crucial method in chemical synthesis, enabling the synthesis functional organic molecules. In recent decades, transition metal‐catalyzed hydrosilylation highly successful exemplar industrialization within realm chemistry for production organosilanes, which have pivotal role and materials science. Precious metal complexes are typically employed catalysts most industrial processes. exploration Earth‐abundant alternatives focal point considerable research attention due to high cost, poor selectivity, many side reactions reported precious catalysts. Ligand skeleton construction, mechanism areas where cobalt more potential than iron nickel. This review discusses advances cobalt‐catalyzed across carbon‐carbon, carbon‐oxygen, carbon‐nitrogen multiple bonds from 2019 2023.

Язык: Английский

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Recent Advances in Nonprecious Metal Catalysis

Organic Process Research & Development, Год журнала: 2024, Номер 28(4), С. 937 - 948

Опубликована: Март 21, 2024

Significant emphasis has been placed on the development of nonprecious metal alternatives to precious-metal-catalyzed reactions due lower cost and greater sustainability they can achieve. This review is part a series describing advances in nonprecious-metal-catalyzed transformations published between March June 2023 that are relevant pharmaceutical process chemistry.

Язык: Английский

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Co‐Catalyzed Hydrosilylation of Ketones under Base‐Free Conditions: A Convenient Route to Silyl Ethers or Secondary Alcohols

ChemCatChem, Год журнала: 2023, Номер 15(18)

Опубликована: Июль 24, 2023

Abstract A cobalt‐catalyzed addition of hydrosilanes to unsaturated carbon‐oxygen bonds has been developed, relying on complexes featuring easily accessible and inexpensive PNP‐type pincer ligands. wide range heterocyclic, aliphatic, aromatic ketones, including those containing both electron‐donating electron‐withdrawing substituents, were transformed into silyl ethers or secondary alcohols with high yields. An important feature this protocol is that silanes can act as the substrates activators, eliminating need for external additives such strong bases.

Язык: Английский

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Unveiling the Reactivity of Part Per Million Levels of Cobalt‐Salen Complexes in Hydrosilylation of Ketones

Chemistry - A European Journal, Год журнала: 2024, Номер 30(46)

Опубликована: Июнь 10, 2024

A series of air-stable cobalt(III)salen complexes Co-1 to Co-4 have been synthesized and employed in the hydrosilylation ketones. Notably, most intricately tailored Co-3 pre-catalyst exhibited exceptional catalytic activity under mild reaction conditions. The developed protocol proceeded with an unusual ppm level (5 ppm) catalyst loading achieved a maximum turnover number (TON) 200,000. wide variety aromatic, aliphatic, heterocyclic ketones encompassing both electron-donating electron-withdrawing substituents were successfully transformed into desired silyl ethers or secondary alcohols moderate excellent yields.

Язык: Английский

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Structural and Reactivity Implications of Homo- and Heterobimetallic Co(II) Amides Prepared via Trans(amination) Reactions

Organometallics, Год журнала: 2024, Номер 44(1), С. 197 - 206

Опубликована: Дек. 3, 2024

Язык: Английский

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Synthesis and biological evaluation of panaxadiol ester derivatives possessing pyrazole and pyrrole moiety as HIF-1α inibitors

Fitoterapia, Год журнала: 2024, Номер 177, С. 106052 - 106052

Опубликована: Июнь 6, 2024

Язык: Английский

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