An Oxidant-Free and Mild Strategy for Quinazolin-4(3H)-One Synthesis via CuAAC/Ring Cleavage Reaction DOI Creative Commons

Yueling He,

Zhong‐Tao Yang,

Danyang Luo

и другие.

Molecules, Год журнала: 2023, Номер 28(15), С. 5734 - 5734

Опубликована: Июль 28, 2023

An oxidant-free and highly efficient synthesis of phenolic quinazolin-4(3H)-ones was achieved by simply stirring a mixture 2-aminobenzamides, sulfonyl azides, terminal alkynes. The intermediate N-sulfonylketenimine underwent two nucleophilic additions the group eliminated through power aromatization. natural product 2-(4-hydroxybenzyl)quinazolin-4(3H)-one can be synthesized on large scale under mild conditions with this method.

Язык: Английский

Unveiling the role of Lewis bases in cascade furan Diels–Alder cycloadditions: asymmetric synthesis of polycyclic quinazolinones DOI
Yuhan Li, Dongyi Zhang, Zhonglin Wei

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(19), С. 5488 - 5494

Опубликована: Янв. 1, 2024

A Lewis base catalyzed asymmetric substitution/IMDAF reaction for the synthesis of polycyclic quinazolinones has been developed. The key role in IMDAF process unveiled.

Язык: Английский

Процитировано

0
Alkaloids from Mackinlaya species and synthetic mackinazolinone derivatives: An overview DOI Creative Commons

Julie Jaouen,

Christian Bailly

Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 117, С. 118018 - 118018

Опубликована: Ноя. 23, 2024

Язык: Английский

Процитировано

0
An Oxidant-Free and Mild Strategy for Quinazolin-4(3H)-One Synthesis via CuAAC/Ring Cleavage Reaction DOI Creative Commons

Yueling He,

Zhong‐Tao Yang,

Danyang Luo

и другие.

Molecules, Год журнала: 2023, Номер 28(15), С. 5734 - 5734

Опубликована: Июль 28, 2023

An oxidant-free and highly efficient synthesis of phenolic quinazolin-4(3H)-ones was achieved by simply stirring a mixture 2-aminobenzamides, sulfonyl azides, terminal alkynes. The intermediate N-sulfonylketenimine underwent two nucleophilic additions the group eliminated through power aromatization. natural product 2-(4-hydroxybenzyl)quinazolin-4(3H)-one can be synthesized on large scale under mild conditions with this method.

Язык: Английский

Процитировано

0