Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110338 - 110338
Опубликована: Авг. 1, 2024
Язык: Английский
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110338 - 110338
Опубликована: Авг. 1, 2024
Язык: Английский
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 10, 2024
Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited systems substrate scope. Herein, we report an enantioselective azidation/click cascade reaction N-propargyl-β-ketoamides with readily available potent azido transfer reagent via copper catalysis, which affords variety up 99% yield 95% ee under mild conditions. Notably, 1,5-disubstituted triazoles that have not been accessed by previous also prepared good functional group tolerance.
Язык: Английский
Процитировано
6European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(42)
Опубликована: Авг. 19, 2023
Abstract To expand the chemical space of chiral N ‐oxides and furan‐containing ligands, herein we designed synthesized a new class rigid‐featured tertiary amine‐derived C 2 ‐symmetric furan‐ , N′ ‐dioxide (Fu‐2NO) ligands from optically pure l ‐prolinamides/hydroxylprolinamides in operationally simple two steps up to 57 % overall yield. The newly developed Fu‐2NO possesses pyrroloimidazolone‐based as non‐flat walls, afforded opportunity for fine‐tuning ligand electronic conformational properties by judicious choice substituent nonligating nitrogen atom. More importantly, can tolerate air moisture such that no special handling is needed their storage, be applied Ni(II)‐catalyzed asymmetric Friedel‐Crafts alkylation reaction indole.
Язык: Английский
Процитировано
7Catalysts, Год журнала: 2023, Номер 13(9), С. 1243 - 1243
Опубликована: Авг. 26, 2023
The functionalization of unactivated substrates through the combination copper catalysts and hypervalent iodine reagents represents a versatile tool in organic synthesis to access various classes compounds. derivatives can be used simply as oxidizing agents regenerate catalytic species or they associate starting material. In this review, special attention will paid methodologies which provide introduction nucleophiles into reagent by use suitable benziodoxol(on)es iodonium salts. Many reactions concern C- N-arylations, but may also involve formation different carbon–carbon carbon–nitrogen bonds, carbon–oxygen well carbon–halogen carbon–phosphorus bonds.
Язык: Английский
Процитировано
6Organic Letters, Год журнала: 2024, Номер 26(25), С. 5312 - 5317
Опубликована: Июнь 13, 2024
Cu-catalyzed asymmetric construction of a chiral quaternary center bearing CH3 and CF3 groups was achieved with high to excellent enantioselectivity using our originally developed ligands. The conjugate addition Me3Al β-CF3-substituted enones unsaturated ketoesters proceeded efficiently. use gives optically active furanones in yields enantioselectivities. perfluoroalkyl-substituted enone does not seem be favorable the present reaction.
Язык: Английский
Процитировано
2Chemistry - A European Journal, Год журнала: 2023, Номер 30(5)
Опубликована: Окт. 17, 2023
Diazomethyl-substituted iodine(III) compounds with electron-withdrawing groups (EWG) connected to diazo methyl center were a type of donor-acceptor potential reaction abilities similar ordinary compounds. Although several diazomethyl-substituted synthesized and used in the nucleophilic substitution reactions as early 1994, synthesis application new have only been reported certain extent recent years. In presence rhodium catalyst, photocatalyst, or nucleophiles, can be converted into rhodium-carbenes, diazomethyl radicals, ester radicals intermediates, which key intermediates for formation chemical bonds. The aim this review is give an overview organic synthesis.
Язык: Английский
Процитировано
5Acta Chimica Sinica, Год журнала: 2023, Номер 81(11), С. 1590 - 1590
Опубликована: Янв. 1, 2023
a 华东师范大学化学与分子工程学院 石油化工分子转化与反应工程全国重点实验室 上海分子治疗与新药创制工程 技术研究中心 上海市绿色化学与化工过程绿色化重点实验室 上海 200062) ( b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 200032
Процитировано
5Journal of Catalysis, Год журнала: 2023, Номер 429, С. 115275 - 115275
Опубликована: Дек. 27, 2023
Язык: Английский
Процитировано
5Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Авг. 20, 2024
Organic nitrates, as effective donors of the signaling molecule nitric oxide, are widely applied in pharmaceutical industry. However, practical and efficient methods for accessing organic nitrates still scarce, achieving high regiocontrol unactivated alkene difunctionalization remains challenging. Here we present a simple method highly regioselective halonitrooxylation alkenes. The approach utilizes TMSX (X: Cl, Br, or I) oxybis(aryl-λ
Язык: Английский
Процитировано
1Tetrahedron Chem, Год журнала: 2024, Номер unknown, С. 100114 - 100114
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1Organic Chemistry Frontiers, Год журнала: 2023, Номер 11(2), С. 336 - 342
Опубликована: Ноя. 22, 2023
A concise electrocatalytic Mn-oxidative C(sp 3 )–H azidation approach is described. This protocol offers mild reaction conditions, broad substrate scope, and the potential for achieving enantioselective azidation.
Язык: Английский
Процитировано
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