Synthesis and Utilization of 1H-Indazole N-Oxides in the Production of C3-Functionalized 1H-Indazoles DOI
Jin Kyoon Park, Sagar Arepally

Synthesis, Год журнала: 2024, Номер 56(20), С. 3108 - 3118

Опубликована: Апрель 30, 2024

Abstract The medicinal importance, natural rarity, and challenges associated with the synthesis of C3-functionalized 1H-indazoles have propelled development novel practical 1H-indazole N-oxides for production diverse arrays 1H-indazoles. use has been remarkably effective selective introduction functional groups, including amino (NHAr), chloro (Cl), hydroxy (OH), sulfonyl (SO2Ar), aromatic (Ar), olefin, alkyl, N-formyl (NRCHO) to indazole pharmacophore molecules. This review offers a concise overview synthetic approaches applications N-oxides, recent studies conducted by authors. Transformative reactions involving not only offer strategies synthesizing but also hold significant potential in chemistry. 1 Introduction 2 Synthetic Approaches Applications 1H-Indazole N-Oxides 3 Summary Outlook

Язык: Английский

Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents DOI Creative Commons
Akira Yoshimura, Viktor V. Zhdankin

Chemical Reviews, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Hypervalent iodine(III) compounds have found wide application in modern organic chemistry as environmentally friendly reagents and catalysts. iodine are commonly used synthetically important halogenations, oxidations, aminations, heterocyclizations, various oxidative functionalizations of substrates. Iodonium salts arylating reagents, while iodonium ylides imides excellent carbene nitrene precursors. Various derivatives benziodoxoles, such azidobenziodoxoles, trifluoromethylbenziodoxoles, alkynylbenziodoxoles, alkenylbenziodoxoles group transfer the presence transition metal catalysts, under metal-free conditions, or using photocatalysts photoirradiation conditions. Development hypervalent catalytic systems discovery highly enantioselective reactions chiral represent a particularly recent achievement field chemistry. Chemical transformations promoted by many cases unique cannot be performed any other common, non-iodine-based reagent. This review covers literature published mainly last 7-8 years, between 2016 2024.

Язык: Английский

Процитировано

33

Expeditious Synthesis of Spiroindoline Derivatives via Tandem C(sp2)–H and C(sp3)–H Bond Functionalization of N-Methyl-N-nitrosoanilines DOI

Wang Kelin,

Yu‐Qian Sun, Bin Li

и другие.

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3091 - 3096

Опубликована: Апрель 3, 2024

Presented herein is a novel synthesis of pharmaceutically privileged spiroindoline derivatives via cascade reactions N-methyl-N-nitrosoanilines with diazo homophthalimides. A group mechanistic studies disclosed that the formation product involves an unusual reaction mode N-methyl-N-nitrosoaniline featuring initial C(sp2)–H bond activation/alkylation followed by C(sp3)–H activation/spiroannulation. To our knowledge, this first example in which acts as C3N1 synthon to accomplish formal [4+1] spiroannulation participation N-methyl unit rather than previously reported C2N1 undergo [3+2] annulation without unit. In general, newly developed synthetic protocol features simple and readily accessible starting materials, valuable products, unique mechanism, high efficiency atom-economy, excellent compatibility diverse functional groups, ready scalability.

Язык: Английский

Процитировано

17

Synthesis of functionalized quinolines from the cascade reactions of N-aryl amidines with two CF3-ynones via C–H/N–H/C–N/C–C bond cleavage DOI
Hao Li,

Shengnan Yan,

Yuanshuang Xu

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(7), С. 1917 - 1923

Опубликована: Янв. 1, 2024

We present a novel synthesis of CF 3 - and alkynyl-substituted quinoline derivatives based on Rh( iii )-catalyzed cascade reactions N -aryl amidines with two -ynones. Then, some products are transformed into polycyclic -benzo[ k ]phenanthridines through an intramolecular annulation reaction.

Язык: Английский

Процитировано

14

Synthesis of CF3–Isoquinolinones and Imidazole-Fused CF3–Isoquinolinones Based on C–H Activation-Initiated Cascade Reactions of 2-Aryloxazolines DOI

Miaomiao Liang,

Shengnan Yan,

Yuanshuang Xu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 10180 - 10196

Опубликована: Июль 4, 2024

Presented herein are novel syntheses of CF

Язык: Английский

Процитировано

9

Synthesis of Naphtho[1′,2′:4,5]furo[3,2-b]pyridinones via Ir(III)-Catalyzed C6/C5 Dual C–H Functionalization of N-Pyridyl-2-pyridones with Diazonaphthalen-2(1H)-ones DOI
Yuanshuang Xu,

Yujing Xiao,

Xinying Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(4), С. 786 - 791

Опубликована: Янв. 22, 2024

Presented herein is an unprecedented synthesis of naphtho[1′,2′:4,5]furo[3,2-b]pyridinones via Ir(III)-catalyzed C6/C5 dual C–H functionalization N-pyridyl-2-pyridones with diazonaphthalen-2(1H)-ones. This protocol forms C–C and C–O bonds in one pot which diazonaphthalen-2(1H)-ones serve as bifunctional reagents, providing both alkyl aryloxy sources. To the best our knowledge, this first example title compounds by using substrates. Notably, method features operational simplicity, good functional group tolerance, high efficiency, atom economy.

Язык: Английский

Процитировано

8

Synthesis of Indenone-Fused Pyran Derivatives from Aryl Enaminones and Cyclopropenones through Unsymmetrical Relay C–H Bond Activation and Double C–C/C–O Bond Formation DOI

Chun Xia Yang,

Bin Li, Xinying Zhang

и другие.

Organic Letters, Год журнала: 2024, Номер 26(31), С. 6602 - 6607

Опубликована: Июль 30, 2024

Presented herein is a novel synthesis of indenone-fused pyran derivatives via the cascade reactions aryl enaminones with cyclopropenones. The formation products involves one-pot procedure consisting C–H bond and enamine functionalization along C–C cleavage cyclopropenone 1,3-rearrangement in situ-formed allylic alcohol moiety followed by intramolecular O-nucleophilic addition Me2NH elimination. To our knowledge, this first simultaneous both indenone scaffolds through concurrent unsymmetrical relay activation double C–C/C–O formation. Moreover, usefulness method further showcased its suitability for large-scale synthetic scenarios diverse transformations products.

Язык: Английский

Процитировано

8

Application of Sulfoxonium Ylides or Iodonium Ylides in Rhodium‐Catalyzed Synthesis of Phenanthrenes DOI
Xiao Liu, Bingxin Zhou, Kelu Yan

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(8), С. 1744 - 1750

Опубликована: Фев. 22, 2024

Abstract The transmetalation triggered rhodium‐catalyzed C−H bond activation and tandem annulation of 2‐biphenylboronic acids with sulfoxonium ylides or iodonium has been developed. Various products phenanthrenes were constructed under redox‐neutral conditions in 34–86% yields. Several mechanism exploration experiments derivatization reactions conducted sequence to gain a deeper understanding the process potential this transformation. It offers an alternative approach for synthesis phenanthrene derivatives.

Язык: Английский

Процитировано

6

Synthesis of CF3-Substituted N-Heterocyclic Compounds Based on C–H Activation-Initiated Formal [2 + 3] Annulation Featuring with a Latent Nucleophilic Site DOI

Manqing Wang,

Shengnan Yan,

Bin Li

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(11), С. 7828 - 7842

Опубликована: Май 22, 2024

Presented herein is a novel synthesis of CF

Язык: Английский

Процитировано

6

Divergent synthesis of pyrrolizine derivatives through C−H bond functionalization of pyrroles DOI

Manqing Wang,

Yuanshuang Xu,

Huihang Hou

и другие.

Chemical Communications, Год журнала: 2024, Номер 60(51), С. 6536 - 6539

Опубликована: Янв. 1, 2024

Presented herein is the synthesis of diversely functionalized pyrrolizines from reaction

Язык: Английский

Процитировано

5

Synthesis of CF3-Azafluorenes through the Cascade Reaction of 2H-Imidazoles with CF3-Ynones DOI
Hao Li,

Shengnan Yan,

Chunhua Ma

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

A concise synthesis of trifluoromethyl (CF

Язык: Английский

Процитировано

5