The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 425 - 432
Опубликована: Дек. 12, 2023
Spirobenzofuran
scaffolds,
because
of
their
three-dimensional
structure,
are
incorporated
into
several
valuable
natural
products
and
drug
candidate
molecules.
Herein,
with
the
assistance
electrosynthesis,
we
introduce
a
novel
electrochemical
approach
for
achieving
spirobenzofurans
in
user-friendly
operationally
simple
undivided
cell
setup
under
constant
current.
This
metal-catalyst-free
procedure
afforded
spiro[benzofuran-2,2′-furan]-3-ones
high
diastereoselectivity.
Compatibility
gram-scale
synthesis
along
convenient
accessibility
reaction
instruments
starting
materials
collectively
raised
importance
this
protocol
compared
to
previous
challenging
methods.
Furthermore,
mechanistic
cognizance
is
obtained
by
investigation
cyclic
voltammetry
spectra
reactants.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(7), С. 4673 - 4683
Опубликована: Март 13, 2024
The
cascade
electrochemical
C3-selective
aerobic
oxygenation
of
2-substituted
indoles
and
[5
+
3]
annulation
with
amidines
through
an
undivided
cell
galvanostatic
method
employing
molecular
oxygen
"electricity"
as
green
oxidants
was
developed.
This
protocol
provides
efficient
direct
approach
to
eight-membered
benzo[1,3,5]triazocin-6(5H)-ones.
Mechanistic
studies
suggested
that
two
subsequent
processes
both
proceeded
radical
pathways.
Chemical Communications,
Год журнала:
2024,
Номер
60(57), С. 7351 - 7354
Опубликована: Янв. 1, 2024
Cp
2
Fe-mediated
electrochemical
synthesis
of
a
diverse
array
phosphorylated
azaspiro[4.5]di/trienones
has
been
developed,
which
demonstrated
broad
substrate
scope
and
good
diastereoselectivity.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
A
multicomponent
[2+2+1]
tandem
cyclization
of
alkynones
with
amines
and
water
using
potassium
thiocyanate
as
electrolyte
raw
material
to
access
thiazol-2(3
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
Due
to
its
unique
three-dimensional
(3D)
configuration
and
great
application
potential
in
medicinal
chemistry
synthetic
community,
chemists
have
been
pursuing
concise
efficient
methods
synthesize
C3
spirocyclic
indoline
derivatives.
In
this
work,
a
dearomatization–spirocyclization–nucleophilic
addition
tandem
approach
was
developed
realize
the
synthesis
of
2-phosphonylated
indolines
with
indolyl-ynones
phosphine
oxides
as
reactants;
mild
conditions,
broad
substrate
scope,
good
yields
are
characteristics
transformation.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
89(1), С. 425 - 432
Опубликована: Дек. 12, 2023
Spirobenzofuran
scaffolds,
because
of
their
three-dimensional
structure,
are
incorporated
into
several
valuable
natural
products
and
drug
candidate
molecules.
Herein,
with
the
assistance
electrosynthesis,
we
introduce
a
novel
electrochemical
approach
for
achieving
spirobenzofurans
in
user-friendly
operationally
simple
undivided
cell
setup
under
constant
current.
This
metal-catalyst-free
procedure
afforded
spiro[benzofuran-2,2′-furan]-3-ones
high
diastereoselectivity.
Compatibility
gram-scale
synthesis
along
convenient
accessibility
reaction
instruments
starting
materials
collectively
raised
importance
this
protocol
compared
to
previous
challenging
methods.
Furthermore,
mechanistic
cognizance
is
obtained
by
investigation
cyclic
voltammetry
spectra
reactants.
