Angewandte Chemie, Год журнала: 2024, Номер unknown
Опубликована: Дек. 13, 2024
Abstract Oxetanes are valuable motifs in medicinal chemistry applications, with demonstrated potential to serve as bioisosteres for an array of functional groups. Through the visible‐light‐mediated photoredox hydrodecarboxylation 2‐aryl oxetane 2‐carboxylic acids this work enables access products a [2+2]‐photocycloaddition between alkenes and aryl aldehydes without challenges associated traditional UV‐light‐mediated Paternò‐Büchi reaction. Investigation into mechanism reveals substrate‐dependent modes initiation under conditions reported herein. Divergence diastereomeric outcome is observed, mechanistic probes elucidating key hydrogen‐bonding steric interactions.
Язык: Английский