The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

We successfully reported selective C–H alkynylation of 2-pyridones with bromoalkynes under the catalysis Co(III) or Ru(II). The reaction used easily accessible instead high-valent iodine alkynes. There is a broad substrate scope good yields. In addition, 2-pyridone can be as weakly directing group for proximal aryl bond. This method offers an efficient approach synthesizing diverse derivatives, yielding alkynylated products up to 95% yield (>40 examples).

Язык: Английский