Science Advances, Год журнала: 2023, Номер 9(35)

Опубликована: Сен. 1, 2023

Empowered by the ubiquity of carbonyl functional groups in organic compounds, decarbonylative functionalization was prevalent construction complex molecules. Under this context, asymmetric has emerged as an efficient pathway to accessing chiral motifs. However, ablation enantiomeric control a conventional 2e transition metal–catalyzed process notable because harsh conditions (high temperatures, etc.) that are usually required. To address challenge and use readily accessible aldehyde directly, we report radical azidation cyanation. Diverse aldehydes were directly used alkyl precursor, engaging subsequent inner-sphere or outer-sphere ligand transfer where motifs (CN N 3 ) could be incorporated excellent site- enantioselectivity. Mild conditions, broad scope, regioselectivity (driven polarity-matching strategy), enantioselectivity shown for both transformations. This strategy using precursor offered powerful reaction manifold transformations construct regio- stereoselectively.

Язык: Английский