Molecules, Год журнала: 2023, Номер 28(20), С. 7021 - 7021
Опубликована: Окт. 10, 2023
Under the catalysis of Rh2(OAc)4 (10 mol%) and binapbisphosphine ligand (±)-L3 (20 in DCE at 80 °C, cascade cyclization diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-fused oxa-bridged oxazocines reasonable chemical yields. The structure relative configuration title products were firmly identified by X-ray diffraction analysis.
Язык: Английский
Chemical Science, Год журнала: 2024, Номер 15(34), С. 13942 - 13948
Опубликована: Янв. 1, 2024
While cycloaddition reactions of bicyclobutanes (BCBs) have emerged as a potent method for synthesizing (hetero-)bicyclo[
Язык: Английский
Процитировано
24
Organic Letters, Год журнала: 2023, Номер 25(51), С. 9213 - 9218
Опубликована: Дек. 15, 2023
Herein we employed ethynylethylene carbonates (EECs) to achieve formal [4 + 1] and [3 3] cycloaddition with cyclic 1,3-dicarbonyl compounds. On one hand, EECs styryl substitution could undergo a remotely controlled enantioselective reaction. This reaction exhibits good chemoselectivity, regioselectivity, enantioselectivity. In addition, of compounds was also achieved, leading series 4H-pyrans impressive chemoselectivity
Язык: Английский
Процитировано
21
Organic Letters, Год журнала: 2024, Номер 26(8), С. 1589 - 1594
Опубликована: Фев. 22, 2024
This study demonstrates a highly efficient regiodivergent ligand-controlled palladium-catalyzed cycloaddition reaction of vinyloxazolidine-2,4-diones with 1,3,5-triazinanes. In the presence diphosphine ligand, proceeds via (5+2) pathway to afford 1,3-diazepin-4-ones in excellent yields, while using monophosphine smoothly (3+2) give imidazolidin-4-ones good yields.
Язык: Английский
Процитировано
9
Advanced Science, Год журнала: 2024, Номер 11(31)
Опубликована: Июнь 17, 2024
Abstract Oxazocines are key structural intermediates in the synthesis of natural products and pharmaceutical molecules. However, oxazocines especially a highly enantioselective manner, is long‐standing formidable challenge due to unfavorable energetics involved cyclization. Herein, series new PNP‐Ligand P ‐chiral stereocenter first designed synthesized, called MQ‐Phos , successfully applied it Pd‐catalyzed higher‐order formal [4+4]‐cycloaddition α β ‐unsaturated imines with 2‐(hydroxymethyl)‐1‐arylallyl carbonates. The reaction features mild conditions, excellent regio‐ enantiocontrol broad substrate scope (54 examples). Various medium‐sized rings can be afforded moderate yields (up 92%) enantioselectivity 99% ee). newly developed critical for ring catalytic reactivity enantioselectivity.
Язык: Английский
Процитировано
6
Chinese Journal of Chemistry, Год журнала: 2023, Номер 42(8), С. 829 - 834
Опубликована: Дек. 8, 2023
Comprehensive Summary The Pd‐catalyzed dipolar cycloaddition represents a significant synthetic strategy for the construction of useful heterocyclic compounds. This study developed [4+2] and [6+2] reactions benzo[ d ]isothiazole 1,1‐dioxides (BDs) leading to synthesis BD‐fused 1,3‐oxazinane 1,3‐oxazocane derivatives, respectively. In particular, 1,3‐oxazinanes demonstrated regio‐ enantioselective characteristics, resulting in products with good yields, enantioselectivity regioselectivity (if applicable). Furthermore, reaction this work represented first medium‐sized ring compounds based on BDs.
Язык: Английский
Процитировано
9
Chemical Communications, Год журнала: 2023, Номер 59(97), С. 14467 - 14470
Опубликована: Янв. 1, 2023
The construction of medium-sized ring compounds has been a prominent research area in synthetic chemistry. In this study, we developed tandem strategy that combines allylic amination and ring-opening oxetanes to synthesize heterocycles. Specifically, N-aryl oxetan-3-amines undergo with zwitterionic π-allylpalladium, followed by intramolecular ring-opening, resulting the formation Notably, are able achieve synthesis 7-8 membered heterocycles moderate good yields employing different types π-allylpalladium species.
Язык: Английский
Процитировано
8
Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 22(2), С. 252 - 268
Опубликована: Ноя. 28, 2023
Eight-membered heterocycles are important but their synthesis is usually challenging. This review summarizes the recent advances in [4 + 4] annulation of conjugated heterodienes with 1,4-dipolar species for assembling eight-membered heterocycles.
Язык: Английский
Процитировано
7
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(10), С. 2864 - 2869
Опубликована: Янв. 1, 2024
A novel palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates has been developed for the synthesis bridged eight-membered oxygen heterocycles in good yields and excellent stereoselectivities.
Язык: Английский
Процитировано
2
Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(40), С. 8162 - 8169
Опубликована: Янв. 1, 2023
The zwitterionic π-allylpalladium species, also known as dipoles, are important synthons widely used in various reactions including cycloaddition and allylic substitution. This study reported the development of a new indole-fused precursor compound its application [4 + 2] substitution reactions. As result, synthesis pyrrolo[3,2,1-ij]quinazolin-3-one 7-vinyl indole compounds was achieved with moderate to good yields. Notably, reaction exhibited excellent regio- stereoselectivity.
Язык: Английский
Процитировано
5
Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(48), С. 9507 - 9518
Опубликована: Янв. 1, 2023
This review summarizes Pd-catalyzed oxa-[4 + n ] dipolar cycloadditions of 1,4-O/C dipoles with diverse dipolarophiles, affording five- to nine-membered O-heterocycles.
Язык: Английский
Процитировано
4