Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis

Chemical Reviews, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Cross-electrophile coupling (XEC), defined by us as the cross-coupling of two different σ-electrophiles that is driven catalyst reduction, has seen rapid progression in recent years. As such, this review aims to summarize field from its beginnings up until mid-2023 and provide comprehensive coverage on synthetic methods current state mechanistic understanding. Chapters are split type bond formed, which include C(sp

Язык: Английский

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Stereoretentive Conversion to C-Glycosides from S-Glycosides via Ligand-Coupling on Sulfur(IV)

Organic Letters, Год журнала: 2025, Номер 27(4), С. 954 - 960

Опубликована: Янв. 21, 2025

A novel strategy is reported for the stereoselective synthesis of C(sp2)-C(sp3) C-glycosides, which converts heteroaryl S-glycosides into C-glycosides with retention configuration through a sequential process involving oxidation and Grignard reagent attack. The new method involves generation S(IV) intermediate, followed by ligand coupling glycosyl groups to yield C-glycosides. diverse were achieved good efficiency.

Язык: Английский

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Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(11), С. 3124 - 3130

Опубликована: Янв. 1, 2024

A metal-free method for the synthesis of ketones via a visible-light induced denitrogenative alkylation vinyl azides with alkyl radicals is presented.

Язык: Английский

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Photoredox/nickel dual-catalyzed deaminative cross-electrophile for allenylic alkylation with non-activated alkyl katritzky salts

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(20), С. 5685 - 5694

Опубликована: Янв. 1, 2024

The first allenylic alkylation with non-activated aliphatic amine derivatives, Katritzky salts, has been developed via photoredox/nickel dual-catalyzed reductive deaminative cross-electrophile coupling.

Язык: Английский

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Catalytic ring-strain release toward a facial and efficient synthesis of versatile C-glycosides

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110560 - 110560

Опубликована: Окт. 1, 2024

Язык: Английский

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Photoreductive Alkylative Dearomatization of N‐Alkyl Pyridin‐1‐ium Salts: Site Selective Access to 4‐Alkyl 1,4‐Dihydropyridines

European Journal of Organic Chemistry, Год журнала: 2023, Номер 27(3)

Опубликована: Ноя. 28, 2023

Abstract A visible light photoreductive dearomatizative alkylation of N ‐alkyl pyridinium salts for producing 4‐alkyl‐1,4‐dihydropyridines is described. The reaction harnesses both as the alkyl radical precursors to initiate and 1,4‐dihydropyridin‐4‐yl‐based alkylating reagents terminate reaction. In contrast reported electroreductive procedure via key dihydropyridine intermediates, mechanistic studies demonstrate that this proceeds directly addition across ring followed by single electron oxidant (SEO) dearomatization.

Язык: Английский

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Concise synthesis of 3-C-glycosyl isocoumarins and 2- glycosyl-4H-chromen-4-ones

Chemical Communications, Год журнала: 2024, Номер 60(75), С. 10390 - 10393

Опубликована: Янв. 1, 2024

A new Ru-catalyzed C-H activation/cyclization reaction for the synthesis of 3-

Язык: Английский

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