Modular Synthesis of α‐Quaternary Chiral β‐Lactams via Three‐Component Asymmetric Kinugasa/Aldol or Kinugasa/Mannich Cascade Reactions DOI Open Access

Linxuan Wang,

Jialin Qi, Haoyu Li

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

The β-lactam scaffolds are the prevalent structural units in antibiotics and natural products. Herein, three-component asymmetric Kinugasa/aldol Kinugasa/Mannich cascade reactions have been developed for constructing α-quaternary chiral β-lactams. This method involved tandem reaction of alkynes, nitrones aldehydes (or imines), resulting formation three sequential stereocenters controlled by copper(I) catalysts bis(oxazolidine) ligands. protocol features high enantioselectivity, good efficiency, mild operational conditions, representing a practical sustainable synthetic tool construction functionalized

Язык: Английский

Catalytic C–C Bond Forming Reaction to Imines DOI
Branislav Kokić, Ana Andrijević, Igor Opsenica

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1

Recent Advances in Nonprecious Metal Catalysis DOI
Archita Sripada, Eugene Chong, Hao Wu

и другие.

Organic Process Research & Development, Год журнала: 2024, Номер 28(9), С. 3524 - 3544

Опубликована: Авг. 9, 2024

Developing catalytic reactions using nonprecious-metal to achieve various synthetic transformations remains a valuable pursuit the scientific community. As part of continuing review series that is published within precompetitive chemistry alliance between AbbVie, Boehringer Ingelheim and Pfizer, this article underscores wide-ranging uses Cu-, Co-, Fe-, Ni-catalysis. The significant uptick in NPMC-related publications signifies escalating curiosity among researchers investigate advance capabilities these metals.

Язык: Английский

Процитировано

1

Modular Synthesis of α‐Quaternary Chiral β‐Lactams via Three‐Component Asymmetric Kinugasa/Aldol or Kinugasa/Mannich Cascade Reactions DOI Open Access

Linxuan Wang,

Jialin Qi, Haoyu Li

и другие.

Chemistry - A European Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

The β-lactam scaffolds are the prevalent structural units in antibiotics and natural products. Herein, three-component asymmetric Kinugasa/aldol Kinugasa/Mannich cascade reactions have been developed for constructing α-quaternary chiral β-lactams. This method involved tandem reaction of alkynes, nitrones aldehydes (or imines), resulting formation three sequential stereocenters controlled by copper(I) catalysts bis(oxazolidine) ligands. protocol features high enantioselectivity, good efficiency, mild operational conditions, representing a practical sustainable synthetic tool construction functionalized

Язык: Английский

Процитировано

1