Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
β-(Trifluoromethyl)styrenes
are
potentially
useful
building
blocks
for
the
synthesis
of
organofluorine
compounds
because
their
electron-deficient
C=C
double
bonds
can
undergo
diverse
transformations.
One
most
practical
methods
preparing
β-(trifluoromethyl)styrenes
is
decarboxylative
trifluoromethylation
readily
available
cinnamic
acid
derivatives
using
Langlois
reagent
as
a
less
expensive
trifluoromethyl
source.
We
revisited
electrochemical
to
identify
modified
conditions
that
reduce
loading
without
additional
additives.
The
reaction
mechanism
was
computationally
investigated
gain
insight
into
dependence
product
yields
on
aryl
terminal
groups.
synthetic
utility
obtained
demonstrated
by
transformation
4-aryl-3-(trifluoromethyl)pyrrolidines.
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 3069 - 3074
Опубликована: Апрель 1, 2024
Free
radical
three-component
nitration/spirocyclization
of
unsaturated
sulfonamides/amides
with
tert-butyl
nitrite
was
developed
for
the
construction
diverse
NO2-revised
4-azaspiro[4.5]decanes.
This
tandem
system
featured
metal-free
participation,
simple
operation,
good
selectivity/yields,
and
a
green/low-cost
O
source.
Meanwhile,
one
nitro-containing
complex
molecule
scaled-up
operation
were
performed
well
to
test
synthetic
potential
cascade
reaction.
Isotopic
labeling,
inhibition
experiments,
DFT
analysis
carried
out
gain
insight
into
reaction
process.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(4), С. 2718 - 2725
Опубликована: Фев. 2, 2024
An
anodically
oxidizing
trifluoromethylation
cascade
of
N-cyanamide
alkene
bearing
two
electronically
differentiated
olefin
moieties
was
reported,
in
which
various
N-unsaturated
acyl
cyanamide
alkenes
and
CF3SO2Na
acting
as
readily
available
starting
materials
furnished
nonaromatic
fused
azaheterobicyclic
compounds
a
highly
efficient
sustainable
manner.
The
broad
substrate
scope,
facile
scalability,
sustainability
enabled
this
electrochemical
process
to
be
an
appealing
complement
for
trifluoromethylated
cyclic
amidines.
Green Chemistry,
Год журнала:
2024,
Номер
26(12), С. 7419 - 7423
Опубликована: Янв. 1, 2024
We
have
developed
a
straightforward
electrochemical
protocol
for
direct
α-amidation
and
α-pyrazolation
of
N
-alkoxy-
-aryloxycarbonyl
pyrrolidines
with
amides
or
pyrazoles.
Vinyl
sulfonates
are
vital
intermediates
in
organic
synthesis,
serving
as
versatile
electrophiles
various
cross-coupling
reactions.
Despite
their
significance,
direct
methods
for
synthesizing
vinyl
from
styrenes
have
been
limited.
In
this
study,
we
introduce
an
innovative
electrochemical
approach
that
leverages
bromine
radical
mediation
to
facilitate
the
synthesis
of
sulfonates,
cheap
nBu4NBr
acts
both
electrolyte
and
a
catalytic
amount.
This
process
involves
reaction
with
sodium
sulfinates
water
under
conditions,
offering
straightforward
pathway
these
compounds.
The
developed
strategy
is
characterized
by
its
high
efficiency,
operational
simplicity,
environmentally
benign
nature,
adhering
principles
green
chemistry
while
ensuring
atom
economy
remarkable
regioselectivity.
Furthermore,
methodology
proves
effective
gram-scale
allows
subsequent
functionalization
sulfonate
products
pharmaceutical
derivatives,
thus
broadening
potential
applications
techniques
styrene
functionalization.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 4708 - 4715
Опубликована: Янв. 1, 2024
A
simple
and
practical
visible
light-driven
photoredox-catalyzed
three-component
carbotrifluoromethylation
of
alkenes
is
revealed
for
the
synthesis
1,4-bis(trifluoromethylated)
compounds.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(18), С. 13117 - 13127
Опубликована: Сен. 3, 2024
A
strategy
for
convenient
and
precise
oxidative
aminotrifluoromethylation
of
1,4-naphthoquinone
with
the
Togni
reagent
amines
has
been
demonstrated
via
a
radical
process.
This
method
allows
efficient
access
preparation
wide
range
CF
Chemical Communications,
Год журнала:
2024,
Номер
60(59), С. 7614 - 7617
Опубликована: Янв. 1, 2024
A
mild
and
efficient
electrochemical
method
for
radical
addition,
cyclization,
migration
reaction
was
described
in
this
work.
difluoromethyl
produced
by
anodizing
CF
