Abstract
(Trifluoromethyl)sulfanyl
compounds
have
garnered
significant
attention
in
medicinal
chemistry,
agrochemistry,
and
materials
science
due
to
their
unique
physicochemical
properties,
including
high
lipophilicity,
metabolic
stability,
strong
electron-withdrawing
ability.
This
review
pro-vides
a
comprehensive
overview
of
the
current
methods
for
synthesis
(trifluoromethyl)sulfanyl
compounds,
highlighting
recent
advances
emerging
strategies.
Key
synthetic
approaches,
such
as
direct
(trifluoromethyl)sulfanylation,
transition-metal-catalyzed
processes,
radical-based
are
discussed
with
an
emphasis
on
substrates
reagents.
The
chapter
also
briefly
introduces
mechanistic
insights
role
novel
reagents
enhancing
efficiency
selectivity
these
transformations.
Green Chemistry,
Год журнала:
2024,
Номер
26(11), С. 6774 - 6778
Опубликована: Янв. 1, 2024
A
novel
and
attractive
photochemical
difunctionalization
of
N
-tosyl
acrylamide
for
constructing
alkylsulfonylated
oxindoles
amides
with
excellent
substrate
adaptability
via
a
radical
Smiles
rearrangement
strategy
is
described.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(17), С. 2023 - 2028
Опубликована: Апрель 30, 2024
Comprehensive
Summary
A
general
and
broadly
applicable
copper
photoredox
dual‐catalyzed
multicomponent
1,4‐perfluoroalkylcyanation
of
1,3‐enynes
has
been
developed.
This
protocol
enjoys
success
with
high
regioselectivity,
mild
reaction
conditions,
excellent
functional‐group
tolerance,
allowing
the
facile
synthesis
structurally
diverse
perfluoroalkylated
allenes
from
readily
available
fluoroalkyl
halides,
TMSCN
in
a
one‐pot
manner.
reasonable
mechanism
proposed
according
to
series
control
experiments.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(15), С. 4284 - 4289
Опубликована: Янв. 1, 2024
A
three-component
reaction
of
aldehyde-derived
hydrazones
with
DABSO
and
aryldiazonium
tetrafluoroborates
is
described.
Moreover,
the
photocatalyzed
sulfonylation
can
also
be
achieved
from
sulfonyl
chlorides.
A
new
three-component
1,2-perfluoroalkyl
trifluoromethylthiolation
of
alkenes
via
dual
photoredox/copper
catalysis
has
been
established,
affording
a
variety
CnF2n+1/CF3S-containing
molecules
under
mild
conditions
in
redox-neutral
manner.
This
protocol
exhibits
excellent
functional
group
tolerance,
broad
compatibility
with
various
and
perfluoroalkyl
iodides,
potential
utility
the
modification
bioactive
molecules.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Quinolines,
a
significant
part
of
nitrogen-containing
heterocycles,
are
widely
found
in
functional
compounds.
Herin,
photochemical
radical
cyclization
reaction
o-vinylaryl
isocyanides
and
aryldiazonium
tetrafluoroborates,
has
been
reported
to
build
2,4-diaryl
quinolines.
Readily
accessible
aryl
diazonium
salts
were
utilized
as
precursors
at
room
temperature.
This
approach
allowed
good
group
tolerance
substrate
applicability.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(7), С. 1975 - 1981
Опубликована: Янв. 1, 2024
A
novel
alkyl
radical-initiated
alkylsulfonylation
of
alkenes
involving
copper
carbene
coupling
is
developed
for
the
synthesis
various
alkyl–alkyl
sulfones
by
employing
potassium
metabisulphite
(K
2
S
O
5
)
as
a
connector.
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(12), С. 5101 - 5106
Опубликована: Янв. 1, 2024
A
reductive
cross-coupling
strategy
for
the
synthesis
of
sulfone-containing
oxindoles
was
presented.
Moreover,
using
amines
instead
alkyl
bromides,
a
palladium-catalyzed
domino
cyclization/aminosulfonylation
also
established.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(22), С. 6340 - 6346
Опубликована: Янв. 1, 2024
We
developed
the
first
transition-metal-catalyzed,
regiodivergent
sulfonylation
of
aziridines,
enabling
efficient
synthesis
diverse
β-amino
sulfones
under
mild
conditions
with
broad
substrate
compatibility
and
high
regioselectivity.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(16), С. 1853 - 1859
Опубликована: Апрель 17, 2024
Comprehensive
Summary
An
alkyl
radical
initiated
cyclization/tandem
reaction
of
bromides
and
electrophiles
by
using
potassium
metabisulphite
(K
2
S
O
5
)
as
a
connector
is
developed
for
the
synthesis
various
lactam‐substituted
sulfones.
Notably,
this
process
does
not
require
metal
catalyst
or
powder
reductant,
highlighting
its
environmentally
friendly
features.
The
demonstrates
outstanding
substrate
adaptability
high
tolerance
towards
diverse
functional
groups.
Furthermore,
biologically
active
molecules
commercially
available
drugs
with
late‐stage
modification
are
also
highly
compatible
transformation.
Mechanistic
studies
revealed
that
proceeds
through
single‐step
involving
intramolecular
cyclization,
"SO
"
insertion,
external
incorporation.
