Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
The hydrofluorination of enynoates has been developed for the synthesis fluorinated dienoates.
Язык: Английский
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Biological organisms contain bioactive macromolecules such as amino acids, which serve basic materials for constructing cells and repairing tissues. Due to the unique properties of fluorine atom, can alter structure proteins increase their lipophilicity, incorporating a atom into acids has become research hotspot. In this study, ethyl 3-bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate was synthesized from glycine derivatives. Under alkaline conditions, compound reacted with 2-aminophenol generate benzoxazole-containing acid derivative. This method is simple operate, without metal participation, performed under relatively eco-friendly reaction providing novel approach synthesis benzoxazole heterocycles.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111167 - 111167
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2023, Номер 26(1), С. 376 - 379
Опубликована: Дек. 28, 2023
We herein describe a diastereoselective Pd(0)-catalyzed Hiyama cross-coupling reaction of gem-difluoroalkenes. The use organosilicon reagents in this is advantageous over other organometallic by allowing the introduction wide range functional groups, including challenging alkyl groups. Also conveniently, additive TBAF was not required for (hetero)aryl-substituted difluoroalkenes.
Язык: Английский
Процитировано
9
Organic Letters, Год журнала: 2024, Номер 26(6), С. 1261 - 1264
Опубликована: Фев. 1, 2024
We herein describe a straightforward protocol for the synthesis of carboxylic esters containing gem-difluoromethylene unit. Readily available acids can act as nucleophiles to add regioselectively tetrasubstituted or trisubstituted β,β-difluoroacrylates (formal hydroacetoxylation) construction RCO2–CF2 bonds. Thermal conditions are sufficient without use catalysts additives.
Язык: Английский
Процитировано
2
Organic Letters, Год журнала: 2024, Номер 26(17), С. 3591 - 3596
Опубликована: Апрель 25, 2024
A palladium-catalyzed defluorinative alkylation of gem-difluoroalkenes with cyclopropyl alcohols was developed. range γ-fluorinated γ,δ-unsaturated ketones were constructed in good yields excellent stereoselectivities. In addition, by base-mediated intramolecular nucleophilic vinylic substitution (SNV), the products could be further transformed to 2,5-dimethylenetetrahydrofurans and analogues
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2024, Номер 26(27), С. 5822 - 5826
Опубликована: Июнь 27, 2024
We herein describe a stereodivergent C-F bond functionalization of
Язык: Английский
Процитировано
1
Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 2691 - 2703
Опубликована: Окт. 24, 2024
In this study, we develop the synthesis methods of fluoroalkenes and fluoroenynes via Suzuki–Miyaura Sonogashira cross-coupling reactions using novel multihalogenated fluorovinyl ethers, which are easily prepared from reaction between phenols 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane). These make use unique structure contains a reactive bromine atom, to afford series in moderate high yields.
Язык: Английский
Процитировано
0
Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
The hydrofluorination of enynoates has been developed for the synthesis fluorinated dienoates.
Язык: Английский
Процитировано
0