Construction of Benzoxazole and Isoquinoline Compounds via Base-Mediated Cyclization of Amino Acid Derivatives

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Biological organisms contain bioactive macromolecules such as amino acids, which serve basic materials for constructing cells and repairing tissues. Due to the unique properties of fluorine atom, can alter structure proteins increase their lipophilicity, incorporating a atom into acids has become research hotspot. In this study, ethyl 3-bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate was synthesized from glycine derivatives. Under alkaline conditions, compound reacted with 2-aminophenol generate benzoxazole-containing acid derivative. This method is simple operate, without metal participation, performed under relatively eco-friendly reaction providing novel approach synthesis benzoxazole heterocycles.

Язык: Английский

Photoredox-catalyzed synthesis of α,α-difluoromethyl-β-alkoxysulfones from sulfur dioxide

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 109926 - 109926

Опубликована: Апрель 1, 2024

Язык: Английский

Pd^II/Cu^I-Cocatalyzed Radical Arylation of gem-Difluoroalkenes Using Arylsulfonyl Chlorides

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

A Pd

Язык: Английский