Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 4, 2024
The
preparation
of
enantioenriched
diarylmethanol
derivatives
is
described
using
nickel-catalyzed
electrochemical
cross-couplings
between
various
alkyl/aryl
aldehydes
and
aryl
iodides.
Performed
in
an
cell
equipped
with
iron
anode
a
nickel
cathode,
this
electrocatalytic
variant
led
to
the
scalemic
targeted
products
presence
2,2-bis((4
R,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)acetonitrile
(L2),
as
enantiopure
cyano-bis(oxazoline)
ligand.
X-ray
structure
analysis
pre-catalyst,
for
instance
[Ni
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(5), С. 1314 - 1321
Опубликована: Янв. 1, 2024
A
new
class
of
chiral
bipyridine-2NO
ligands,
which
incorporate
the
advantages
both
bipyridine
skeleton
and
pyrroloimidazolone-based
N
-oxide
moiety,
was
developed.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(10)
Опубликована: Ноя. 28, 2023
Asymmetric
hydrogenation
finds
widespread
application
in
academia
and
industry.
And
indeed,
a
number
of
processes
have
been
implemented
for
the
production
pharma
agro
intermediates
as
well
flavors
&
fragrances.
Although
these
are
all
based
on
use
late
transition
metals
catalysts,
there
is
an
increasing
interest
base
metal
catalysis
view
their
lower
cost
expected
different
substrate
scope.
Catalysts
cobalt
already
shown
potential
enantioselective
chemistry.
This
review
outlines
impressive
progress
made
recent
years
cobalt-catalyzed
asymmetric
unsaturated
substrates.
We
also
illustrate
ligand
dependent
specificity
mechanistic
variability
detail.
may
guide
further
catalyst
development
this
research
area.
JACS Au,
Год журнала:
2023,
Номер
3(11), С. 2981 - 2986
Опубликована: Окт. 20, 2023
Based
on
an
amino-group-assisted
coordination
strategy
and
a
proton-shuttle-activated
outer-sphere
mode,
the
cobalt-catalyzed
asymmetric
hydrogenation
of
α-primary
amino
ketones
has
been
developed,
resulting
in
efficient
synthesis
chiral
vicinal
alcohols
bearing
functionalized
aryl
rings
high
yields
enantioselectivities
(up
to
99%
enantiomeric
excess
(ee))
within
0.5
h.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Despite
the
extensive
literature
on
ferrocene
chemistry,
a
comprehensive
analysis
of
multiferrocene
ligands
is
notably
absent.
Thus,
this
review
presents
an
overview
multiferrocenyl-containing
ligands,
focusing
their
synthesis,
characterization,
and
applications
in
catalysis
sensing.
These
offer
unique
properties,
including
redox
activity
planar
chirality,
making
them
valuable
asymmetric
molecular
electronics.
The
covers
from
first
synthesis
tris(ferrocenyl)phosphane
1962
to
current
developments,
various
ligand
subsets,
which
contain
at
least
two
units
within
structure.
Special
attention
given
explaining
coordination
electrochemical
behavior,
practical
these
ligands.
aim
undertaking
fill
gaps
knowledge
inspire
further
research
by
identifying
areas
for
exploration.
Notably,
certain
families
like
TRAP
(trans-spanning
phosphane)
remain
underexplored
terms
highlighting
opportunities
future
investigation.
provides
resource
researchers
field,
stimulating
advancements
multiferrocenyl
chemistry
its
wide-ranging
applications.
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(15), С. 6670 - 6675
Опубликована: Янв. 1, 2024
A
new
class
of
C
2
-symmetric
rigid-featured
chiral
phen
ligands
that
provide
the
N
,
O
-tetradentate
coordination
moiety
and
two
additional
-dioxides
were
rationally
designed
developed.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(38), С. 26416 - 26426
Опубликована: Сен. 16, 2024
The
transition
metal-catalyzed
asymmetric
hydrogenation
(AH)
of
ketones
to
produce
enantioenriched
alcohols
is
an
important
reaction
in
organic
chemistry
with
applications
the
pharmaceutical
and
agrochemical
fields.
Using
earth-abundant,
biorelevant
cobalt
as
central
metal
catalyst
has
a
high
potential
improve
sustainability
achieve
reactions
that
are
scalable.
However,
due
d-electron
count,
designing
catalysts
exhibit
turnover
numbers
(TONs,
≥1000)
enantioselectivities
(≥90%)
sufficient
for
synthetic
utility
practical
scalability
(≥1
kg
scale)
remains
challenge.
In
this
work,
efficient
design
strategy
utilizing
amino(imino)diphosphine
Co(II)
bromide
precatalyst
presented
goal.
quantitative
production
wide
range
secondary
chiral
TONs
up
150,000
enantiomeric
excess
(e.e.)
99%
at
scale
1.35
was
achieved,
indicating
proposed
highly
promising
AH
scale-up
reactions.
A
mechanistic
study
revealed
synergism
N-H
functionality
redox-active
ligand
endows
productivity
excellent
enantioselectivity.
Abstract
Phosphine
oxides
are
an
interesting
class
of
compounds
possessing
tetracoordinate
and
pentavalent
phosphorus
atoms
have
been
employed
in
a
wide
range
applications
including
reagents
organic
synthesis,
metal
extractants,
flame
retardants,
pharmaceuticals,
bioactivity
studies.
Among
all,
the
degree
basicity
phosphoryl
oxygen
driven
by
nature
substituents
influences
electronic
properties
central
complex
toward
diversified
catalytic
processes.
Further,
presence
heteroatoms
adjacent
to
atom
enhances
nucleophilicity
atom.
In
view
this,
present
review
covers
past
two
decades
remarkable
versatility
P=O‐based
complexes
describes
governing
factors
influencing
structural
resultant
coordination
behavior.
Interestingly,
some
P=O
bond
distances
either
longer
or
shorter
compared
their
free
ligands,
indicating
activity.
These
can
effectively
catalyze
chemical
reactions
polymerizations,
C−C
Si−C
activations,
oxidation,
reduction,
hydroformylation,
hydrophosphination,
hydrogenation
cyclization
reactions.
Furthermore,
this
emphasizes
impact
substituents,
solvents,
additives,
light,
temperature
on
efficiency.
