Divergent synthesis of pyrrolizine derivatives through C−H bond functionalization of pyrroles
Chemical Communications,
Год журнала:
2024,
Номер
60(51), С. 6536 - 6539
Опубликована: Янв. 1, 2024
Presented
herein
is
the
synthesis
of
diversely
functionalized
pyrrolizines
from
reaction
Язык: Английский
Organocatalytic Enantioselective Synthesis of Polycyclic Benzosultams from 2-Amino-β-nitrostyrenes with Cyclic N-Sulfonyl Ketimines
Organic Letters,
Год журнала:
2024,
Номер
26(7), С. 1472 - 1477
Опубликована: Фев. 13, 2024
A
highly
efficient
enantioselective
[4
+
2]
cycloaddition
of
2-amino-β-nitrostyrenes
with
cyclic
N-sulfonyl
ketimines
has
been
developed.
This
reaction
utilizes
an
organocatalytic
approach,
employing
a
multiple-hydrogen-bonding
bifunctional
squaramide-based
catalyst.
The
process
allows
for
the
precise
synthesis
chiral
polycyclic
benzosultams,
showcasing
intricate
structures
that
incorporate
quaternary
centers.
Noteworthy
outcomes
this
method
include
high
yields
excellent
enantioselectivities
and
diastereoselectivities
(up
to
97%
yield,
96%
ee,
>20:1
dr).
Язык: Английский
Enantioselective Construction of Spirooxindole‐γ‐butyrolactones via NHC‐Bound Isobenzofulvene [10π+2π] Cycloaddition
Chinese Journal of Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Comprehensive
Summary
We
report
an
N
‐heterocyclic
carbene
(NHC)‐catalyzed
[10π+2π]
cycloaddition
between
indene‐2‐carbaldehydes
and
isatins,
delivering
spirooxindole‐γ‐butyrolactones
with
moderate
yields
(up
to
68%)
excellent
enantioselectivity
93%
ee).
This
transformation
proceeds
via
NHC‐bound
isobenzofulvene
intermediates
represents
the
first
successful
application
of
all‐carbon
higherene
in
NHC‐catalyzed
cycloadditions.
Язык: Английский