Ligand-Enabled Nickel(II)-Catalyzed β-C(sp3)–H Thiolation of Ketones DOI
Lili Chen, Gang Liao, Bin Liu

и другие.

Organic Letters, Год журнала: 2024, Номер 26(42), С. 9103 - 9107

Опубликована: Окт. 15, 2024

We present the first example of nickel(II)-catalyzed β-C(sp3)–H thiolation ketones, employing 2-hydrazinopyridine as an efficient directing group. This approach enables a diverse array ketones at β-position. The straightforward installation and subsequent removal group significantly enhance synthetic versatility practicality this transformation.

Язык: Английский

Unified approaches in transition metal catalyzed C(sp3)–H functionalization: recent advances and mechanistic aspects DOI
Jagrit Grover,

Amal Tom Sebastian,

S.K. Maiti

и другие.

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Direct alteration of unactivated C–H bonds organic building blocks.

Язык: Английский

Процитировано

1
Chiral Ligands for Palladium-Catalyzed Coordination-Assisted Enantioselective C(sp3)—H Functionalization Reactions DOI
Chen‐Hui Yuan, Lei Jiao

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 602 - 602

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Site-selective C(sp3)–H functionalization of primary aliphatic amines DOI
Ye Tao,

Kaige Guo,

Hao Chen

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(11), С. 3270 - 3280

Опубликована: Янв. 1, 2024

C–H bond functionalization represents one of the most efficient and straightforward strategies for diversifying existing molecules.

Язык: Английский

Процитировано

3
Unveiling the Mechanistic Role of Chiral Palladacycles in Pd(II)‐Catalyzed Enantioselective C(sp3)−H Functionalization DOI
Chen‐Hui Yuan, Xiaoxia Wang,

Keyun Huang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(29)

Опубликована: Май 7, 2024

Palladium-catalyzed enantioselective C(sp

Язык: Английский

Процитировано

2
Directed C(sp3)-H Arylation of Free α-Aminophosphonates: Dual Models Exploration via Palladium Catalysis DOI

Li−Na Yi,

Tao Zhao,

Jinghan Bu

и другие.

Organic Letters, Год журнала: 2024, Номер 26(19), С. 4132 - 4136

Опубликована: Май 8, 2024

In this report, we present the dual activation models for transient directing group-directed and amino-self-directed Pd-catalyzed α-aminophosphonate side-chain C(sp3)-H arylation. Both strategies showed facile, efficient, single regioselectivity in reaction between free α-aminophosphonates aryl iodides. Furthermore, modification of amino late-stage functionalization C(sp3)-P bond from products indicates potential applications α-aminophosphonates.

Язык: Английский

Процитировано

2
Palladium-Catalyzed Selective γ-Monoarylation of Free Amines Containing Symmetric γ-C–H Controlled by a Transient Directing Group DOI

Sifan Dong,

Xinghao Cai,

Chen Ma

и другие.

Organic Letters, Год журнала: 2024, Номер 26(29), С. 6153 - 6158

Опубликована: Июль 10, 2024

We developed a new transient directing group,

Язык: Английский

Процитировано

2
Unveiling the Mechanistic Role of Chiral Palladacycles in Pd(II)‐Catalyzed Enantioselective C(sp3)−H Functionalization DOI
Chen‐Hui Yuan, Xiaoxia Wang,

Keyun Huang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер 136(29)

Опубликована: Май 7, 2024

Abstract Palladium‐catalyzed enantioselective C(sp 3 )−H functionalization reactions has attracted considerable attention due to its ability for the synthesis of enantiomerically enriched molecules and stimulation novel retrosynthetic disconnections. Understanding reaction mechanism, especially stereochemical process reaction, is crucial rational design more efficient catalytic systems. Previously, we developed a Pd(II)/sulfoxide‐2‐hydroxypridine (SOHP) system asymmetric reactions. In this study, focused on unraveling chemistry chiral palladacycles involved in Pd(II)‐catalyzed functionalization. We have isolated key palladacycle intermediates β‐C(sp arylation carboxylic acids catalyzed by Pd(II)/SOHP system. These palladacycles, exhibiting ligand‐induced chirality, provided significant opportunity investigate ligand effect C−H Our investigation direct evidence palladation step as enantioselectivity‐determining step, which forms diastereomeric that exhibited preservation chirality step. DFT calculations insights into induction formation. This work highlights value offering mechanistic

Язык: Английский

Процитировано

0
Ligand-Enabled Nickel(II)-Catalyzed β-C(sp3)–H Thiolation of Ketones DOI
Lili Chen, Gang Liao, Bin Liu

и другие.

Organic Letters, Год журнала: 2024, Номер 26(42), С. 9103 - 9107

Опубликована: Окт. 15, 2024

We present the first example of nickel(II)-catalyzed β-C(sp3)–H thiolation ketones, employing 2-hydrazinopyridine as an efficient directing group. This approach enables a diverse array ketones at β-position. The straightforward installation and subsequent removal group significantly enhance synthetic versatility practicality this transformation.

Язык: Английский

Процитировано

0