Transition‐Metal Catalyzed [4+2]‐Cycloaddition Reactions: A Sexennial Update DOI
Jasmine Panda,

Suhasini Mohapatra,

Mohammed Ansar Ahemad

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(12)

Опубликована: Март 21, 2024

Abstract Cycloaddition reactions serve as exceptionally useful strategy to provide atom‐economical, efficient and practical access complex molecules from simple starting materials. The [4+2]‐cycloaddition reaction allows for the stereospecific construction of six‐membered carbo‐/heterocycles. catalyzed by transition metals are potent methods rapid highly functionalized molecular frameworks. This review article summarizes different reports on transition‐metal involving various such Pd, Cu, Rh, Au, Fe, Ni, Sc, Sn, Hf, Ag, Mn, Dy, Co etc. straightforward pharmaceutically active heterocycles. An emphasis is laid mechanistic insights highlight unique application novel processes transition‐metals in these transformations build intricate polycyclic structures.

Язык: Английский

Fully atom-economic access to spiro-cyclic skeletons through photoredox-induced hydrogen transfer/Giese addition/dearomative cyclization/protonation cascade DOI
Guohui Zeng,

Hui Luo,

Kai Jiang

и другие.

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(11), С. 3165 - 3172

Опубликована: Янв. 1, 2024

Amine-tethered spiro-cyclic skeletons were obtained through photo-induced 100%-atom-economic dearomatization, involving the cleavage of α-C(sp 3 )–H amines. Pentacyclic framework was achieved from pyridinyl ring within two steps.

Язык: Английский

Процитировано

5

6.1 Palladium-Catalyzed Dearomative Functionalization of Arenes DOI
Kei Muto, Junichiro Yamaguchi

Опубликована: Янв. 1, 2025

Abstract Palladium catalysis plays a pivotal role in organic synthesis, encompassing applications cross-couplings and hydrogenations, among other transformations. Recent progress palladium chemistry has helped enable catalytic dearomative functionalizations. In particular, involving benzyl–palladium species been applied to achieve functionalization of wide range aromatic systems, including challenging substrates such as electronically unbiased benzenes, without the need use an excess amount arene starting materials. This review primarily focuses on via species, incorporating these methodologies synthesis natural products.

Язык: Английский

Процитировано

0

Transition‐Metal Catalyzed [4+2]‐Cycloaddition Reactions: A Sexennial Update DOI
Jasmine Panda,

Suhasini Mohapatra,

Mohammed Ansar Ahemad

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(12)

Опубликована: Март 21, 2024

Abstract Cycloaddition reactions serve as exceptionally useful strategy to provide atom‐economical, efficient and practical access complex molecules from simple starting materials. The [4+2]‐cycloaddition reaction allows for the stereospecific construction of six‐membered carbo‐/heterocycles. catalyzed by transition metals are potent methods rapid highly functionalized molecular frameworks. This review article summarizes different reports on transition‐metal involving various such Pd, Cu, Rh, Au, Fe, Ni, Sc, Sn, Hf, Ag, Mn, Dy, Co etc. straightforward pharmaceutically active heterocycles. An emphasis is laid mechanistic insights highlight unique application novel processes transition‐metals in these transformations build intricate polycyclic structures.

Язык: Английский

Процитировано

1