Fully atom-economic access to spiro-cyclic skeletons through photoredox-induced hydrogen transfer/Giese addition/dearomative cyclization/protonation cascade
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(11), С. 3165 - 3172
Опубликована: Янв. 1, 2024
Amine-tethered
spiro-cyclic
skeletons
were
obtained
through
photo-induced
100%-atom-economic
dearomatization,
involving
the
cleavage
of
α-C(sp
3
)–H
amines.
Pentacyclic
framework
was
achieved
from
pyridinyl
ring
within
two
steps.
Язык: Английский
6.1 Palladium-Catalyzed Dearomative Functionalization of Arenes
Опубликована: Янв. 1, 2025
Abstract
Palladium
catalysis
plays
a
pivotal
role
in
organic
synthesis,
encompassing
applications
cross-couplings
and
hydrogenations,
among
other
transformations.
Recent
progress
palladium
chemistry
has
helped
enable
catalytic
dearomative
functionalizations.
In
particular,
involving
benzyl–palladium
species
been
applied
to
achieve
functionalization
of
wide
range
aromatic
systems,
including
challenging
substrates
such
as
electronically
unbiased
benzenes,
without
the
need
use
an
excess
amount
arene
starting
materials.
This
review
primarily
focuses
on
via
species,
incorporating
these
methodologies
synthesis
natural
products.
Язык: Английский
Transition‐Metal Catalyzed [4+2]‐Cycloaddition Reactions: A Sexennial Update
ChemistrySelect,
Год журнала:
2024,
Номер
9(12)
Опубликована: Март 21, 2024
Abstract
Cycloaddition
reactions
serve
as
exceptionally
useful
strategy
to
provide
atom‐economical,
efficient
and
practical
access
complex
molecules
from
simple
starting
materials.
The
[4+2]‐cycloaddition
reaction
allows
for
the
stereospecific
construction
of
six‐membered
carbo‐/heterocycles.
catalyzed
by
transition
metals
are
potent
methods
rapid
highly
functionalized
molecular
frameworks.
This
review
article
summarizes
different
reports
on
transition‐metal
involving
various
such
Pd,
Cu,
Rh,
Au,
Fe,
Ni,
Sc,
Sn,
Hf,
Ag,
Mn,
Dy,
Co
etc.
straightforward
pharmaceutically
active
heterocycles.
An
emphasis
is
laid
mechanistic
insights
highlight
unique
application
novel
processes
transition‐metals
in
these
transformations
build
intricate
polycyclic
structures.
Язык: Английский