Research on Chemical Intermediates, Год журнала: 2024, Номер 50(3), С. 1497 - 1509
Опубликована: Янв. 29, 2024
Язык: Английский
Organic Letters, Год журнала: 2024, Номер 26(18), С. 3790 - 3795
Опубликована: Апрель 26, 2024
A cooperative gold(I)/DMAP system catalyzes the (2 + 3) cycloadditions of yne-enones with oxindole-derived Morita-Baylis-Hillman (MBH) carbonates, yielding diverse bispiro-cyclopentene oxindole products. The mild, scalable protocol demonstrates broad substrate scope and excellent chemo- diastereoselectivity. Mechanistic study reveals pivotal roles both catalysts in unique cycloaddition. This strategy showcases superiority achieving transformation chemoselectivity diastereoselectivity, unattainable through traditional monocatalytic methodologies.
Язык: Английский
Процитировано
5
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
A novel NIS-promoted domino reaction of alkylidene oxindoles with 2-(pyridin-2-yl)acetate derivatives has been established, enabling the efficient and straightforward synthesis a vast variety highly functionalized indolizines via sequential spiroannulation ring-opening aromatization processes. The protocol features mild conditions, broad substrate scope, high efficiency, scalability, applicability for preparation CF3-containing indolizines. Furthermore, functional groups in indolizine framework provide feasibility follow-up derivatization. Based on mechanistic studies, plausible radical mechanism is proposed to elucidate formation
Язык: Английский
Процитировано
0
Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(12)
Опубликована: Апрель 17, 2024
Abstract We reported a chiral oxamide‐phosphine ligand (COAP−Ph)‐Pd‐catalyzed asymmetric [3+2] cycloaddition reaction between vinyl cyclopropane compounds derived from 1,3‐indanedione and 2‐vinylcyclopropane‐1,1‐dicarboxylates with cyclic sulfonyl 1‐azadienes. The corresponding reactions provided series of enantiomerically active spiro cyclopentane‐indandione cyclopentane structures bearing three consecutive stereogenic centers in good yields diastereo‐ enantioselectivity. COAP−Pd complex serves not only to promote generation π ‐allyl‐palladium intermediates induce the asymmetry reaction, but also depress background reaction.
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 20, 2024
Abstract In this publication, we reported a regio-, diastereoselective, and kinetically controlled reaction for synthesizing thioxothiazolidin-indolin-2-ones, oxoindolin-carbamodithioate hybrids, their base-catalyzed conversion into dispirocyclopentanebisoxindoles. Obtaining only the kinetic thioxothiazolidin-indolin-2-one products together with straightforward to dispirocyclopentanebisoxindoles, excellent regio- diastereoselectivity, easy workup, one-pot synthetic operation are considerable advantages of work.
Язык: Английский
Процитировано
1
Catalysts, Год журнала: 2024, Номер 14(4), С. 219 - 219
Опубликована: Март 22, 2024
In the past few decades, N-heterocyclic carbenes (NHCs) have opened new field of organocatalysis in synthetic organic chemistry. This review highlights dramatic progress NHC-catalyzed C–O bond formation based on activation aldehyde C(sp2)–H bonds. The oxidative and redox transformations for synthesis various molecules with structural diversity complexity are summarized. Furthermore, methods strategies NHC catalysis emerging continuously; thus, cooperative Brønsted acid, hydrogen-bonding catalyst, transition-metal photocatalyst also described.
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2024, Номер 26(19), С. 4077 - 4081
Опубликована: Май 2, 2024
The gold(I)-catalyzed dearomative cyclopentannulation of various indoles with 2-ethynyl-1,3-dithiolane is reported. method generates three new stereocenters excellent control relative stereochemistry and tolerant diverse functionalization substitution patterns on the indoles. obtained cyclopentane-fused indolines allow for interesting subsequent synthetic manipulations, giving rise to fully substituted cyclopentanes all five stereocenters. reported reaction illustrates elucidates a mechanistic dichotomy underlying reactions 2-ethynyl-1,3-dithiolane.
Язык: Английский
Процитировано
0
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 15, 2024
Язык: Английский
Процитировано
0
Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 123 - 173
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 421 - 484
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Research on Chemical Intermediates, Год журнала: 2024, Номер 50(3), С. 1497 - 1509
Опубликована: Янв. 29, 2024
Язык: Английский
Процитировано
0