Cp*Co(III)-catalyzed ortho-alkylation/alkenylation of anilides
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
highly
practical
and
efficient
Cp*Co(
iii
)-catalyzed
regioselective
C–H
alkylation/alkenylation
of
anilides
with
maleimides
acrylates
was
developed,
during
which
a
weakly
coordinating
amide
group
functioned
as
the
directing
group.
Язык: Английский
Electrochemical Esterification Reaction of Alkyne Aldehyde with Alcohols Mediated by Carbene and Iodine
ChemCatChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
A
new
type
of
alkyne
esterification
was
developed
under
electrochemical
conditions
using
aldehydes
and
alcohol
compounds
as
starting
materials
carbene
iodine
mediators.
Through
this
method,
external
oxidants
transition
metals
are
excluded
the
bond
is
fully
preserved.
This
approach
compatible
with
a
wide
range
substrates
various
functional
groups
provides
green
mild
route
for
directly
converting
into
esters.
Язык: Английский
Hydroxyl-Assisted and Co(III)-Catalyzed Redox-Neutral C–H Activation/Directing Group Migration of 2-Pyridones with Propargyl Alcohols: Synthesis of Tetrasubstituted Alkenes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
This
study
provides
a
practical
route
to
synthesize
tetrasubstituted
alkenes
that
involves
Co(III)-catalyzed
C-H
bond
activation
and
regioselective
insertion
of
the
alkyne,
followed
by
chelation
substrate
hydroxyl
Co
migration
pyridine
group.
Density
functional
theory
studies
revealed
origin
regioselectivity
elucidated
crucial
role
group
for
pyridine.
The
method
can
be
conducted
on
gram
scale,
is
compatible
with
wide
range
substrates,
has
high
tolerance.
To
demonstrate
its
significance,
was
used
late-stage
modification
Fasudil.
Furthermore,
synthetic
significance
demonstrated
various
derivatizations
products,
many
which
exhibit
intriguing
fluorescence
characteristics.
Язык: Английский