Chiral guanidine catalyzed cyclization reactions of 1,3-enynes for lactone synthesis: switchable H-bond catalysis

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(10), С. 2897 - 2904

Опубликована: Янв. 1, 2024

Cyclization and 1,4-conjugate addition/cyclization between 2-activated 1,3-enynes azlactones were achieved with chiral guanidine-amides for enol-type activation to yield a range of δ-lactone derivatives.

Язык: Английский

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Pd-Catalyzed Synthesis of Acyclic 1,2-Dioxygenated Dienes and Their Regioselective Decarboxylative Diels–Alder Cycloaddition/Aromatization Reactions to Access Multisubstituted Phenols

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

A Pd-catalyzed protocol that provides efficient access to acyclic 1,2-dioxygenated dienes has been established. The installation of the bifunctional carbonate electrofuge diene cores enabled such undergo a regioselective decarboxylative Diels-Alder cycloaddition/aromatization reaction, affording diverse synthetic challenging multisubstituted phenols with ease.

Язык: Английский

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Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from α-Hydroxy Ketones and Cyano Compounds

Molecules, Год журнала: 2025, Номер 30(8), С. 1832 - 1832

Опубликована: Апрель 19, 2025

A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction α-hydroxy ketones cyano compounds. The proceeds under relatively mild conditions, utilizes readily available starting materials, exhibits good functional group tolerance high yields. Notably, this obviates need expensive metal catalysts introduces crucial groups such as amino moieties. Furthermore, it avoids prerequisite functionalization substrates, thereby enhancing atomic economy.

Язык: Английский

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Recent Developments in Photoinduced Decarboxylative Acylation of α-Keto Acids

Molecules, Год журнала: 2024, Номер 29(16), С. 3904 - 3904

Опубликована: Авг. 18, 2024

Ketones are ubiquitous patterns found in various biological molecules and natural products. In recent years, a number of acylation methods have been developed based on the use α-oxocarboxylic acids as acyl-transfer reagents, with particular emphasis photoinduced decarboxylative

Язык: Английский

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Metal-Free Photoinduced-Radical Hydrocyclization of 2-Isocyanides: A Unified Synthetic Approach to Facilely Assemble Diverse N-Heteroarenes

Green Chemistry, Год журнала: 2024, Номер 26(21), С. 10804 - 10810

Опубликована: Янв. 1, 2024

We present an efficient and sustainable protocol for the photoinduced-radical hydrocyclization of isocyanides, providing a united route to assemble diverse α-unsubstituted N-heteroarenes.

Язык: Английский

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Visible-light-induced decarboxylative cyclization

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

The present review focuses on recent progress (2020–2024) in the visible-light-driven decarboxylative cyclization of various carboxylic acid derivatives for constructing carbo-/heterocycles.

Язык: Английский

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Photoinduced Cross-Coupling of Trifluoromethylarenes with Heteroarenes via Unactivated C(sp³)–F and C(sp²)–H Selective Cleavage

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

The installation of

Язык: Английский

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