Copper-catalyzed bifunctionalization of alkenes with anilines and HFIP: Efficient access to 1,3-amino alcohols
Journal of Catalysis,
Год журнала:
2024,
Номер
429, С. 115292 - 115292
Опубликована: Янв. 1, 2024
Язык: Английский
Palladium/rhodium-catalyzed four-component carbonylative difunctionalization of alkynes: Regio- and stereoselective esterification/selenylation to access β-selenyl acrylates
Journal of Catalysis,
Год журнала:
2025,
Номер
unknown, С. 116170 - 116170
Опубликована: Апрель 1, 2025
Язык: Английский
Photoredox-Catalyzed Synthesis of 3,3-Difluoro-γ-lactams via 1,5-Hydrogen Atom Transfer-Involved Alkyne Difunctionalization and C–N Cleavage
Organic Letters,
Год журнала:
2024,
Номер
26(46), С. 9903 - 9908
Опубликована: Ноя. 8, 2024
This
manuscript
describes
the
application
of
a
1,5-hydrogen
atom
transfer
strategy
in
photoredox-catalyzed
hydrodifluoroalkylation
alkynes.
The
approach
utilizes
sequential
cascade
process
difluoroalkylation,
transfer,
C(sp
Язык: Английский
Modular Synthesis of Cyclic β-Difluoroamines
Chemical Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Fluorine-containing
saturated
nitrogen
heterocycles
are
very
attractive
structures
in
medicinal
and
biological
chemistry
because
fluorine
can
be
used
to
tune
conformation
as
well
key
properties
such
basicity
bioavailability.
At
present
cyclic
fluorinated
amines
accessed
using
hazardous
reagents
DAST
or
by
lengthy
synthesis
routes.
Here
we
report
a
modular
two-step
of
β-fluoroalkyl
photoredox-catalysed
cyclisation/hydrogen
atom
transfer
reaction
bromodifluoroethylamines.
Язык: Английский
EDA-Enabled Three-Component Polarity-Crossover Cyclization: Modular Installation of Fully Substituted γ-Lactams
Organic Letters,
Год журнала:
2024,
Номер
26(44), С. 9598 - 9603
Опубликована: Окт. 28, 2024
A
photoinduced
three-component
radical
addition-aminalization
cascade
was
accomplished,
enabling
rapid
assembly
of
a
wide
range
densely
functionalized
γ-lactams.
Key
to
this
transformation
is
the
electron-donor-acceptor
(EDA)
generation
enamine
and
in
situ
trapping
an
iminium
intermediate
with
bromodifluoroacetamide.
This
rationally
designed
protocol
fully
takes
advantage
polarity
crossover
(enamine-iminium)
process,
providing
modular
previously
inaccessible
scaffolds.
The
reaction
proceeds
under
mild
conditions
excellent
regio-
diastereoselectivity,
which
amenable
structurally
varied
substrates
pharmaceuticals.
Язык: Английский
Cu-catalyzed three-component aminodifluoroalkylative cyclization of styrenes: Access to α,α-difluoro-γ-lactams
Molecular Catalysis,
Год журнала:
2024,
Номер
556, С. 113899 - 113899
Опубликована: Фев. 6, 2024
Язык: Английский
One‐Step Nickel‐Catalyzed Synthesis of Alpha‐Arylidene and Gamma Hydroxy‐Substituted N‐Methyl‐2‐Pyrrolidones
Robin Prakash Sirvin Rajan,
Jungwi Mok,
Junseong Lee
и другие.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(6)
Опубликована: Март 25, 2024
Abstract
This
study
describes
a
method
to
synthesize
compounds
with
an
arylidene
group
at
the
alpha
position
of
N
‐methyl‐2‐pyrrolidone
(NMP)
and
alcohol
gamma
in
single‐step
reaction
using
NMP
aldehyde.
The
highest
yields
were
obtained
Ni(glyme)Cl
2
as
nickel
catalyst
tert
‐butyl
hydroperoxide
oxidant,
various
aryl
aldehydes
reacted
under
optimal
conditions
yield
target
compounds.
Язык: Английский
Photo‐catalyzed Stereospecific Synthesis of Trisubstituted Alkenes Incorporating 3,3‐Difluoro‐γ‐Lactams from Morita‐Baylis‐Hillman Acetates and N‐Allylbromodifluoroacetamides
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
Язык: Английский