Advances and developments in transition metal-free benzylic C(sp³)–H activation/functionalization reactions

RSC Advances, Год журнала: 2025, Номер 15(19), С. 14691 - 14716

Опубликована: Янв. 1, 2025

Transition metal-free benzylic C(sp 3 )–H activation is a direct strategy for forming C–C and C–X bonds. This review highlights C–H activation/annulation or activation/functionalization of toluenes using non-metal catalysts promoters.

Язык: Английский

Multicomponent Synthesis of Tetrahydroisoquinolines

Synfacts, Год журнала: 2024, Номер 20(03), С. 0232 - 0232

Опубликована: Фев. 14, 2024

Key words C–H amination - tetrahydroisoquinolines olefins morpholines multicomponent reaction piperazines azepanes

Язык: Английский

Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium

Molecules, Год журнала: 2024, Номер 29(23), С. 5729 - 5729

Опубликована: Дек. 4, 2024

2-Arylethylamines are presented in several natural bioactive compounds, as well nitrogen-containing drugs. Their ability to surpass the blood-brain barrier makes this family of compounds especial interest medicinal chemistry. Asymmetric methodologies towards synthesis 2-arylethylamine motives great due challenges they may present. Thus, a concise metal-free review presenting recent advances asymmetric 2-arylethylamines is presented, covering last-millennium studies, considering different aforementioned motif, including chiral induction, organocatalysis, organophotocatalysis and enzymatic catalysis.

Язык: Английский