Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
Herein, we report a novel synthetic method for isoxazolidine derivatives through visible-light-induced photoredox cascade cyclization of nitroarenes with triethylamine under aerobic conditions.
Язык: Английский
Organic Letters, Год журнала: 2024, Номер 26(31), С. 6736 - 6741
Опубликована: Июль 29, 2024
A visible-light-induced photoredox three-component carbocyclization reaction of 1,7-enynes with sulfoxonium ylides and water is reported. The protocol provides a facile entry to structurally valuable highly functionalized cyclopenta[c]quinoline scaffolds in chemoselective stereoselective manner. Salient features this method include redox-neutral conditions, no requirement base or other additive, good functional-group tolerance.
Язык: Английский
Процитировано
7
Organic Letters, Год журнала: 2024, Номер 26(12), С. 2398 - 2402
Опубликована: Март 18, 2024
Herein, we introduce a tetralone-mediated photocyclization method of N-arylacrylamides. The protocol proceeds smoothly to deliver diverse set 3,4-dihydroquinolinones in moderate good yields with excellent functional group compatibility and readily allows for late-stage modifications number complex drug molecules. Mechanistic studies reveal that the present systems ultraviolet light irradiation enable cyclization via energy transfer exclusive 1,3-hydrogen shift.
Язык: Английский
Процитировано
6
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Herein, a N-phenylphenothiazine-based hyper-cross-linked polymer (PTH-HCP) was finely designed and constructed, which serves as metal-free heterogeneous photocatalyst for organic transformations. Characterization experiments have shown that this demonstrates outstanding stability, extensive surface area, exceptional photoelectric response properties. Moreover, PTH-HCP showed good catalytic efficiency recyclability in the photochemically driven difluoromethylation/cyclization reactions. This work provides strategy design construction of photocatalysts offers support their broad prospects synthetic applications.
Язык: Английский
Процитировано
0
Organic Chemistry Frontiers, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
We reported the first example of visible-light-induced radical cascade cyclization 2-isocyanobiaryls via 1,5-HAT, which is characterized by broad substrate scope, excellent functional group compatibility and no requirement any metals base.
Язык: Английский
Процитировано
0
European Journal of Organic Chemistry, Год журнала: 2024, Номер 27(41)
Опубликована: Авг. 6, 2024
Abstract A visible‐light‐induced photoredox‐catalyzed radical tandem cyclization of o ‐isocyanodiaryl amines with arylthiodifluoroalkyl 2‐pyridyl sulfones or difluormethyl bromides has been realized for the first time. The reaction works a broad range substrates and provides simple efficient method synthesis 11‐difluoromethyl‐substituted dibenzodiazepines from easily available starting materials in very mild conditions.
Язык: Английский
Процитировано
1
Chinese Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Comprehensive Summary A visible‐light‐induced decarboxylative radical cascade cyclization reaction between N ‐(2‐cyanoaryl)‐acrylamides and alkyl ‐(acyloxy)phthalimide (NHPI esters) for the construction of phenanthridine derivatives has been developed. This approach utilizes lithium iodide (LiI) triphenylphosphine (PPh 3 ) as redox catalysts is produced through photoactivation electron donor‐acceptor (EDA) complex. series primary, secondary, tertiary alkyl‐substituted phenanthridines are prepared in up to 82% yield without transition‐metal catalysts, chemical oxidants, or metal‐/organic dye‐based photocatalysts.
Язык: Английский
Процитировано
1
Green Chemistry, Год журнала: 2024, Номер 26(21), С. 10804 - 10810
Опубликована: Янв. 1, 2024
We present an efficient and sustainable protocol for the photoinduced-radical hydrocyclization of isocyanides, providing a united route to assemble diverse α-unsubstituted N-heteroarenes.
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2024, Номер 26(36), С. 7707 - 7712
Опубликована: Авг. 28, 2024
Herein, we have developed a complementary entry to enable hydroheteroarylation of alkenes involving basically photoredox dearomatizative heterocyclic carbon radical formation through acid-coupled electron transfer followed by Giese addition. While protonic solvent and thiophenol additive enabled two molecular hydroheteroarylations alkenes, the nonproton environment with BF
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Окт. 30, 2024
A visible-light induced intermolecular hydroamination of alkenes with azoles is reported, delivering pharmaceutically valuable N-benzyl in high yields excellent Markovnikov selectivity. Mechanistic studies suggest that the process initiated by energy transfer excited photocatalyst alkenes, followed single electron reduction, protonation, and subsequent oxidation to afford key alkyl carbocation intermediate. This protocol exhibits advantages broad functional group tolerance, atom economy, efficiency, mild reaction conditions.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2024, Номер unknown
Опубликована: Дек. 18, 2024
We herein report a photochemical Truce–Smiles rearrangement reaction of N-sulfinyl acrylamides with bromodifluoroacetamides resulting in the synthesis series aryl difluoroglutaramides moderate to good yields. The asymmetric using chiral sulfinamides produced quaternary carbon-centered glutaramide products modest enantioselectivity. This protocol effectively complements previous methods involving N-sulfonyl acrylamides.
Язык: Английский
Процитировано
0