Palladium/rhodium-catalyzed four-component carbonylative difunctionalization of alkynes: Regio- and stereoselective esterification/selenylation to access β-selenyl acrylates

Journal of Catalysis, Год журнала: 2025, Номер unknown, С. 116170 - 116170

Опубликована: Апрель 1, 2025

Язык: Английский

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Chemoselective Synthesis of α-Halo-α,α-difluoromethyl Ketones from Trimethyl(phenylethynyl)silane

Organic Letters, Год журнала: 2024, Номер 26(21), С. 4508 - 4513

Опубликована: Май 21, 2024

Here, we describe a novel strategy for chemoselective synthesis of α-halo-α,α-difluoromethyl ketones (−COCF3 and −COClCF2 motifs) from trimethyl(phenylethynyl)silane under catalyst-free mild conditions. Commercially available Selectfluor or additional NaCl as halogen reagent was employed to complete this transformation, thereby demonstrating the potential synthetic value new reaction in organic synthesis.

Язык: Английский

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Metal−Free Radical Selenothiocyanation of Terminal and Internal Alkynes

Chemical Communications, Год журнала: 2024, Номер 60(74), С. 10196 - 10199

Опубликована: Янв. 1, 2024

A method for inducing direct selenothiocyanation from both terminal and internal alkynes through a radical process is proposed under metal-free conditions.

Язык: Английский

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Catalytic Aldehyde–Alkyne Couplings Triggered by Ketyl Radicals

Organic Letters, Год журнала: 2024, Номер 26(46), С. 9949 - 9954

Опубликована: Ноя. 8, 2024

A general and flexible platform for catalytic aldehyde-alkyne couplings triggered by ketyl radicals is described. This open-shell strategy necessitates only a quantity of photoredox catalyst, along with Hünig's base (DIPEA) as halogen atom transfer reagent. The reaction proceeds through sequential steps involving activation, transfer, radical addition. carbonyl-alkyne coupling exhibits wide substrate scope functional group compatibility has been successfully applied to the late-stage modification complex architectures.

Язык: Английский

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Silver-Mediated Acetoxyselenylation of Alkynes: Mild Stereoselective Access to Bifunctional Alkenes

Organic Letters, Год журнала: 2024, Номер 26(46), С. 9811 - 9816

Опубликована: Ноя. 13, 2024

Herein, we report a AgF-mediated regio- and stereoselective acetoxyselenylation of terminal/internal alkynes from iodobenzene dicarboxylate [PhI(OCOR)2] diorganyl diselenides via multiple-site functionalization to afford β-selenyl enol esters in good yields. Alkynes derived bioactive molecules, such as l(−)-borneol, l-menthol, acyne oxalate, are also suitable for this transformation the expected compounds.

Язык: Английский

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Cu@CuFe₂O₄ nanoparticles catalyzed oxidative functionalization of alkynes: Access to α,α‐dichloro ketones

Applied Organometallic Chemistry, Год журнала: 2024, Номер 38(8)

Опубликована: Июнь 12, 2024

In this study, novel Cu@CuFe 2 O 4 nanoparticles were prepared by virtue of a simple method. By utilizing compatible system involving N‐chlorosuccinimide (NCS) as the chlorine source and magnetic (NPs) recyclable catalyst, we present practical method for directly obtaining aryl α,α ‐dichloroketones in aqueous trifluoroethanol (TFE). The catalyst was recovered reused up to five times with no significant decrease activity. current study provides foundational raw material subsequent synthesis chlorinated functional molecules, which is achieved through mild transformation arylalkynes using readily available commercial feedstocks exhibiting good tolerance various substituents on aromatic ring, including aliphatic alkyne. This heterogeneous may be used numerous industrial applications because its merits, such considerable recyclability, low requirement loading, cost‐effectiveness, ease handling.

Язык: Английский

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Catalytic Synthesis of Fluoroalkyl Ketones

ChemCatChem, Год журнала: 2024, Номер 16(23)

Опубликована: Авг. 27, 2024

Abstract Fluoroalkyl ketones are a class of structural motifs which ubiquitous in bioactive molecules, and serve as synthons for diverse value‐added fluorine‐containing targets. The presence fluorine significantly alters the lipophilicity bioactivity alkyl well imposes additional challenges on synthesis fluoroalkyl ketones. Traditional methods heavily rely multiple‐step manipulations require stoichiometric reagents suffer from low efficiency. Thus, development synthesizing enabled by catalytic is highly valuable yet challenging. This Concept summarizes recent renaissance developing with substitution patterns different precursors. In addition, further efforts method also discussed.

Язык: Английский

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Late-Stage C-H Trifluoroacetylation of Quinoxaline-2(1H)-ones Using Masked Trifluoroacyl Reagents

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

A strategy for trifluoroacetylation of quinoxaline-2(1 H )-ones has been investigated.

Язык: Английский

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