C3-Heteroarylation of Indoles via Cu(II)-Catalyzed Aminocupration and Subsequent Nucleophilic Addition of o-Alkynylanilines
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Transition-metal-catalyzed
aminometalation
of
o-alkynylanilines
is
a
promising
pathway
for
the
synthesis
C3-functionalized
indoles.
Herein,
we
describe
Cu(II)-catalyzed
site-selective
C3-heteroarylation
indoles
from
and
quinoline
N-oxides.
A
plausible
reaction
mechanism
involving
aminocupration
followed
by
nucleophilic
addition
Cu(II)-indolyl
complexes
to
N-oxides
was
proposed.
Post-transformations
generated
C3-heteroarylated
demonstrated
broad
applicability
developed
method.
Язык: Английский
Synthesis of Quinoline–Indole Hybrids through Cu(II)-Catalyzed Amination and Annulation between N-Oxides and o-Alkynylanilines
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
The
synthesis
of
(iso)quinoline-indole
hybrids
by
reacting
(iso)quinoline
N-oxides
with
o-alkynylanilines
in
the
presence
a
combination
copper(II)
catalyst
and
bidentate
2,2′-bipyridine
ligand
is
described.
utility
this
method
was
demonstrated
through
site-selective
functionalization
synthesized
products.
A
plausible
reaction
pathway
for
amination
followed
annulative
indole
formation
elucidated
series
mechanistic
investigations.
Язык: Английский