Electrochemical Oxidative Reassembly of 1,3-Diketones with Aryl Alkenes and Water via Carbon–Carbon Bond Cleavage Rearrangement
Wei Wu,
R.K. Linghu,
Bingjie Jian
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
We
report
the
electrochemical
cleavage
and
reassembly
of
1,3-diketones
with
aryl
alkenes
water
for
synthesis
1,4-ketoalcohol
derivatives.
This
approach
represents
first
example
formal
carbon-carbon
alkene
insertion
via
electro-oxidation,
enabling
direct
diverse
derivatives
in
good
to
high
yields.
The
developed
strategy
employs
an
using
inexpensive
commercial
carbon
electrodes
undivided
cell
under
mild
operationally
simple
conditions.
Язык: Английский
Iodine-Catalyzed Room-Temperature Aerobic Oxidation of C(sp3)–H Bonds and Its Application in the Synthesis of Quinoxaline Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
An
iodine-catalyzed
aerobic
oxidation
reaction
of
C(sp3)-H
bonds
was
established
at
room
temperature.
In
this
transformation,
iodine
acts
as
a
Lewis
acid
catalyst,
and
the
pyridine
moiety
in
substrate
plays
crucial
role.
Under
optimum
conditions,
picolyl
ketone
substrates
were
smoothly
transformed
into
corresponding
1,2-dicarbonyl
compounds,
subsequent
introduction
1,2-diaminobenzenes
mixture
led
to
formation
various
quinoxaline
derivatives.
This
synthetic
process
does
not
use
transition
metals
also
features
mild
operational
simplicity,
gram-scale
synthesis.
Язык: Английский