Molecular Catalysis, Год журнала: 2024, Номер 572, С. 114789 - 114789
Опубликована: Дек. 24, 2024
Язык: Английский
Green Synthesis and Catalysis, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2025, Номер 90(6), С. 2214 - 2229
Опубликована: Янв. 30, 2025
The selective oxidative cleavage and functionalization of C(OH)–C bonds in tertiary alcohols harbor immense feasibility organic synthesis enable the production high value-added chemicals from renewable biomass. However, it remains a challenge, owing to inherent kinetic inertness thermodynamic stability lack Cα–H. Taking huge potential challenge bond activation into consideration, herein, we show first example an inexpensive bifunctional ferric nitrate catalyst for catalytic direct oxidation structurally distinct esters with environmentally benign molecular oxygen as oxidant MeOH solvent, without assistance any additives. Detailed mechanistic studies reveal that this tandem process is initiated by synergistic effects iron ion ion, which serve Lewis acids dehydrating nitrogen dioxide radical precursor inducing cleavage, respectively.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
This paper presents a novel NHC-BH3-promoted one-step synthesis of disulfides and stibine sulfides using odorless sulfonyl hydrazides. The protocol tolerates various functional groups as well heterocyclic compounds. Mechanistic studies show that NHC-BH3 plays two roles: (1) reducing hydrazides into (2) promoting the cross-coupling chlorostibine with disulfides. synthesized also exhibit satisfactory anticancer activity against 4T1 MDA-MB-231 cancerous cells.
Язык: Английский
Процитировано
0
ACS Catalysis, Год журнала: 2024, Номер unknown, С. 17547 - 17555
Опубликована: Ноя. 13, 2024
In the modern era of organic synthesis, mechanisms centered on radical intermediates have become increasingly impactful. Among all these, hydrogen atom transfer (HAT) represents one most fundamental chemical reaction steps and has found applications in designing practical transformations. Herein, we present a detailed case study selective hydrodefluorination trifluoromethylarenes utilizing N-heterocyclic carbene boranes (NHC-boranes) as donor. Under optimal conditions featuring an acridine-based photocatalyst, complete selectivity for mono-hydrodefluorination was achieved across wide array substrates. Comprehensive mechanistic studies combining experimental computational approaches disproved chain process involving fluorine but rather pointed to HAT non-chain mechanism, where key step involves difluorobenzylic abstracting from NHC-borane generate boryl polarity-matched fashion. Evaluation selection Lewis base-ligated revealed molecular descriptors critical outcomes this reaction, classification model built explain structure–reactivity relationship how various elementary can be influenced. These results collectively provide valuable information future design increase utility chemistry.
Язык: Английский
Процитировано
1
Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(16), С. 4366 - 4370
Опубликована: Янв. 1, 2024
A copper-catalyzed pentafluoroethylation of aryl/alkenyl iodides is described using Et 3 SiCF 2 CF as a direct source. An intriguing selective photocatalytic hydrodefluorination pentafluoroethylarenes also discovered.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Aryl nitriles are highly versatile and useful compounds. A palladium-catalyzed cyanation of diaryl sulfoxides using bench-stable Zn(CN)
Язык: Английский
Процитировано
0
Molecular Catalysis, Год журнала: 2024, Номер 572, С. 114789 - 114789
Опубликована: Дек. 24, 2024
Язык: Английский
Процитировано
0