Discovery of novel benzoxazinone derivatives as promising protoporphyrinogen IX oxidase inhibitors
Pest Management Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Abstract
BACKGROUND
Protoporphyrinogen
IX
oxidase
(PPO,
EC
1.3.3.4)
has
emerged
as
a
key
target
for
developing
new
herbicides
to
protect
crops
from
weeds.
Herein,
we
disclose
the
development
of
two
types
PPO
inhibitors
by
modification
benzoxazinone
skeleton.
RESULTS
Two
structurally
novel
derivatives
containing
hydantoin
or
1,2,3‐triazole
fragments
were
designed
based
on
active
substructure
splicing
and
derivatization
strategies.
Systematic
post‐emergence
herbicidal
activity
studies
crop
selectivity
assessments
indicate
that
some
compounds
exhibit
excellent
safety.
For
instance,
compound
A1
shows
highly
effective
against
all
tested
weeds
at
dosage
150
g
ai/ha.
Particularly,
its
broadleaf
is
comparable
flumioxazin.
Meanwhile,
exhibits
superior
safety
wheat
maize
compared
flumioxazin
within
75–150
ai/ha
range.
Molecular
docking
revealed
occupy
same
cave
Nicotiana
tabacum
(
Nt
PPO).
It
noteworthy
carbonyl
group
oxazolone
moiety
both
forms
beneficial
interactions
with
Arg‐98
Phe‐392.
CONCLUSION
Our
research
indicates
either
serve
promising
chemical
scaffold
PPO‐inhibiting
herbicides.
©
2025
Society
Chemical
Industry.
Язык: Английский
Application of Asymmetric Catalysis in Chiral Pesticide Active Molecule Synthesis
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(31), С. 17153 - 17165
Опубликована: Июль 25, 2024
The
different
configurations
of
chiral
pesticides
generally
have
significant
influence
on
their
biological
activities.
Chiral
agrochemicals
with
high
optical
purities
become
a
prominent
topic
in
the
research
field
new
due
to
advantages
including
lower
toxicity,
higher
efficiency,
and
reduced
residue
levels.
However,
most
commercially
available
that
possess
elements
are
still
used
racemic
forms.
To
date,
asymmetric
catalysis
has
emerged
as
versatile
tool
for
enantioselective
synthesis
various
novel
pesticide
active
molecules.
This
perspective
provides
comprehensive
overview
applications
diverse
catalytic
approaches
facile
preparation
numerous
molecules,
our
own
outlook
future
development
this
highly
direction
is
also
presented
at
end
review.
Язык: Английский
Regio- and Enantioselective N-Heterocyclic Carbene-Catalyzed Annulation of Aminoindoles Initiated by Friedel–Crafts Alkylation
Organic Letters,
Год журнала:
2024,
Номер
26(33), С. 6993 - 6998
Опубликована: Авг. 8, 2024
Chiral
indoles
annulated
on
the
benzene
ring
are
unique
and
significant
in
natural
medicinal
compounds.
However,
accessing
these
enantioenriched
molecules
has
often
been
overlooked.
The
present
study
introduces
an
organocatalytic
protocol
to
access
compounds
efficiently,
demonstrated
by
substrate
scope,
functional
group
tolerance,
using
only
1
mol
%
of
a
chiral
conjugated
acid
catalyst.
Additionally,
explores
regioselectivity,
gram-scale
reactions,
follow-up
transformations,
underscoring
method's
potential.
Язык: Английский
Carbene-Catalyzed Alkylation of Indoles
Synfacts,
Год журнала:
2024,
Номер
20(05), С. 0538 - 0538
Опубликована: Апрель 15, 2024
Язык: Английский
Strategies Employing Transition‐Metal Free Conditions for C−C Bond Formation in Indoles
ChemistrySelect,
Год журнала:
2024,
Номер
9(36)
Опубликована: Сен. 19, 2024
Abstract
Indole
motifs
are
omnipresent
in
nature
and
can
be
found
many
natural
products
as
well
pharmaceuticals.
It
is
for
this
reason
synthetic
transformations
of
indole
have
become
a
topic
interest
the
organic
medicinal
chemist
community
decades.
In
review,
we
emphasized
functionalization
indoles
via
transition‐metal‐free
approaches.
This
review
touches
on
aspects
different
sub‐sections,
which
gives
proposition
tactics
employed
an
overview
road
ahead.
Язык: Английский