Enantioselective Synthesis of Axially Chiral Alkylidenecycloalkanes via Copper-Catalyzed Functionalization of Acyl Allenols
ACS Catalysis,
Год журнала:
2025,
Номер
unknown, С. 2351 - 2358
Опубликована: Янв. 24, 2025
Язык: Английский
Enantio- and E-Selective Copper-Catalyzed Three-Component Hydrofunctionalization of Internal Allenes Bearing Methylidenecyclobutanes with Diborons and Ketones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
Internal
allenes
are
challenging
substrates
in
copper-catalyzed
borylative
difunctionalization.
When
internal
featuring
a
methylidenecyclobutane
motif
were
employed,
hydrofunctionalization
reaction
using
diborons
and
ketones
as
partners
the
presence
of
chiral
monophosphorus
ligand
was
developed,
affording
series
unsaturated
tertiary
alcohols
preserving
high
regio-
stereoselectivities.
Control
experiments
suggest
that
involves
boronation-deboronation
process,
plausible
mechanism
has
been
proposed.
Язык: Английский
Ni-Catalyzed Asymmetric Decarboxylation for the Construction of Carbocycles with Contiguous Quaternary Carbon Stereocenters
Yicheng He,
Biwei Yan,
Cheng Ma
и другие.
Chemical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
The
first
Ni-catalyzed
asymmetric
decarboxylative
strategy
for
the
construction
of
carbocycles
with
contiguous
quaternary
all-carbon
stereocenters
is
reported.
key
to
success
these
reactions
utilization
rationally
designed
allenylic
methylene
cyclic
carbonates
as
substrates
Ni
catalysis.
floppy
group
exerts
unique
electronic
properties
on
carbonate,
which
allows
further
nucleophilic
annulations
alkenes.
These
can
be
performed
at
room
temperature
and
feature
wide
functional
tolerance
excellent
induction
that
typically
>94%
ee.
mechanistic
insights
imply
this
conceptually
new
chemistry
completely
different
from
previous
reports
catalytic
transformation
carbonates,
thus,
it
offers
an
inventive
novel
methodology
create
complex
enantio-enriched
molecules.
Язык: Английский
Pd‐Catalyzed Allylic Substitution using Nucleophilic Amines: Access to Functionalized Mono‐ and Bis‐N‐Allyl Synthons
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(22), С. 4709 - 4714
Опубликована: Авг. 10, 2024
Abstract
We
here
report
a
catalytic
strategy
to
enable
the
decarboxylative
allylic
amination
of
vinyl
cyclic
carbonates
using
various
aliphatic
and
nucleophilic
amines.
The
use
protic
medium
chelating
diphosphine
ligands
are
main
drivers
towards
chemoselective
amine
formation,
thereby
minimizing
undesired
ligand‐driven
complex
speciation
aminolysis
involved
substrate.
This
improved
approach
amplifies
repertoire
synthons
that
can
be
prepared
from
variety
substrate
combinations.
Язык: Английский