Lewis Acid-Catalyzed Intramolecular Cyclization of 7-Alkynylcycloheptatrienes with Carbonyls: Access to 3,4-Disubstituted 2,5-Dihydropyrroles
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
cascade
Lewis
acid-catalyzed
intramolecular
cyclization
of
7-alkynylcycloheptatriene
with
carbonyls
is
reported
herein.
Язык: Английский
One-Pot Total Synthesis of Natural Products Nitramarine, Nitraridine, and Analogues via a Cascade Oxidation/Pictet–Spengler Condensation/Annulation Process
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12832 - 12841
Опубликована: Авг. 9, 2024
A
cascade
oxidation/Pictet–Spengler
condensation/annulation
process
has
been
developed
for
the
one-pot
total
synthesis
of
nitramarine,
nitraridine,
and
their
analogues.
The
procedure
proceeded
with
easily
available
quinolines
tryptophan
derivatives.
simple
metal-free
approach,
wide
substrate
scope,
functional
group
tolerance
make
it
applicable
diverse
bioactive
Furthermore,
bioactivity
evaluation
identified
two
promising
leading
compounds
5d
5e
potent
antitumor
proliferative
activity
against
breast
cancer
cells.
Язык: Английский
Diastereoselective Synthesis of High Functionalized 4‐Imidazolidinone‐Tetrahydro‐beta‐Carboline Hybrids via divergent post‐Ugi Transformation
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2376 - 2381
Опубликована: Март 28, 2024
Abstract
An
easily
scalable
and
highly
diastereoselective
synthesis
of
challenging
1,2,5,6,11,11
b
‐hexahydro‐
3H
‐imidazo[1′,2′:1,2]pyrido[3,4‐
]indol‐3‐ones
is
accomplished
through
divergent
transformation
Ugi
4‐CR
products.
The
trimethylsilyl
trifluoromethanesulfonate
(TMSOTf)
mediated
intramolecular
condensation
a
series
adducts
generates
N
‐acylimidinium
intermediate
which
undergoes
ring
closure
to
selectively
afford
the
target
title
compounds
in
good
high
yields.
Язык: Английский
Access to Piperazine-Fused Pyrrolocarbazoles Enabled by Acid-Catalyzed Stereoselective Hydroarylation of Ynamide–Indoles and Subsequent Diels–Alder Reactions/Aromatizations
Organic Letters,
Год журнала:
2024,
Номер
26(35), С. 7273 - 7278
Опубликована: Авг. 12, 2024
Pyrrolocarbazole
skeletons
are
well
known
to
possess
a
variety
of
biological
activities
that
might
be
therapeutically
useful
in
the
treatment
cancers.
Herein,
an
acid-catalyzed
stereoselective
hydroarylation/Diels–Alder
cycloaddition/aromatization
ynamide–indoles
is
described.
We
newly
designed
and
synthesized
piperazine-fused
pyrrolocarbazole
derivatives
could
further
applied
synthesis
potent
Wee1
inhibitors.
Язык: Английский