Aryne Chemistry: Generation Methods and Reactions Incorporating Multiple Arynes

Chemical Reviews, Год журнала: 2024, Номер 124(20), С. 11435 - 11522

Опубликована: Окт. 9, 2024

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates, advancing construction complex molecular frameworks. Employing multiple equivalents arynes is particularly effective in rapid formation polycyclic cores found optoelectronic materials and bioactive compounds. However, inherent reactivity often leads to side reactions, yielding unanticipated products underlining importance a detailed investigation into use fine-tune their reactivity. This review centers on methodologies syntheses organic reactions involving arynes, categorizing based mechanisms like cycloadditions, σ-bond insertions, nucleophilic additions, ene discusses aryne polymerization. The categorization these includes two primary approaches: first entails engagement within single step while second approach involves using equivalent sequentially across steps, both requiring strict control ensure precise participation each respective step. Additionally, provides an in-depth analysis selection precursors, organized chronologically by activation strategy, offering comprehensive background that supports main theme utilization. expectation remains this will be invaluable designing advanced engaging arynes.

Язык: Английский

Functionalized Quinolones and Isoquinolones via 1,2-Difuntionalization of Arynes: Synthesis of Antagonist Agent AS2717638 and Floxacin Key Intermediates

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Demonstrated herein is a switchable approach for selective synthesis of quinolones and isoquinolones via 1,2-difunctionalization arynes its application in the antagonist agent AS2717638 floxacin key intermediates.

Язык: Английский