From Molecules to Materials: Collaborative Research at the Chemistry—Materials Science Interface and Lessons Learned in Cyclophane Chemistry

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 12, 2024

Abstract In the spirit of pursuing collaborative research at interface chemistry and materials science for engineering cyclophane‐based functional systems, journey from molecules to a portion accomplishments exploring technologically‐relevant small‐molecule organic emitters, polymer thin films, supra‐sensing through supramolecular host‐guest interactions (molecular self‐assembly) is shared. This report highlights diverse trajectories importance active collaboration within community. It also intended serves young scientists who are committed in interdisciplinary domains. inspires fostering global networks promoting industrial−academic symbiosis that bring innovations education environment curriculum by sharing mutual experiences, knowledge, specialized skills which may cut across several inter‐related disciplines.

Язык: Английский

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Multistep Library Synthesis in Flow: Production of Matrix Libraries in an Assembly Line

Опубликована: Май 10, 2024

In drug discovery, automated library synthesis has traditionally focussed on established chemistry such as amide formation or Suzuki coupling. However, to explore a broader chemical space, recent protocols have emphasized increasing the fraction of sp3 hybridized carbons move beyond limitations planar molecules. Herein we present novel approach for multistep in continuous flow, enabling linkage three different elements combinatorial way. To achieve this synthesis, employed nine reactions various combinations. Initially, constructed full library, followed by development multi-transformation libraries where disparate were integrated into single experimental setup, prioritizing chemistries capable introducing C(sp3) fragments while maintaining efficiency. By integrating diverse and optimization capabilities, our method offers powerful means expand diversity discovery libraries.

Язык: Английский

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Assembly line library synthesis in flow: A multistep and multivectorial approach

Опубликована: Июнь 11, 2024

In drug discovery, traditional automated library synthesis has typically involved single-step synthetic procedures targeting a single vector of interest. However, achieving greater structural diversity requires exploring multistep and multivectorial approaches. These methodologies enable the preparation compounds with varying structures in experiment. Here, we present novel method for continuous flow. This approach offers unique opportunities, such as linkers between two defined vectors or rapidly mapping synergistic structure-activity relationship (SAR) by concurrently multiple vectors. Our incorporates up to eight different methodologies, including established chemistries, metal-catalysed transformations, modern metallaphotoredox couplings. broad range ensures high level generated, providing powerful tool accelerate exploration chemical space discovery programs.

Язык: Английский

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Ag–Cu₂O Supported Biomass-Derived rGO for Catalyzing Suzuki–Miyaura Cross-Coupling

Langmuir, Год журнала: 2024, Номер 40(35), С. 18473 - 18485

Опубликована: Авг. 20, 2024

The search for cost-effective, efficient, and ecofriendly heterogeneous catalysts the Suzuki-Miyaura reaction is crucial due to challenges with expensive, toxic homogeneous catalysts. This study centrally aims at crafting a pioneering green catalyst by adorning reduced graphene oxide (rGO), sourced from basil seeds (

Язык: Английский

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Assembly Line Library Synthesis in Flow: A Multistep and Multivectorial Approach

Опубликована: Янв. 1, 2024

Язык: Английский

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