1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
An
acylphosphinylation
reaction
has
been
devised
for
the
synthesis
of
β-aryl-γ-ketophosphine
oxides,
employing
styrenes
and
acyl
azolium
salts
through
an
irradiation-induced
radical
relay
mechanism.
This
method
effectively
constructs
C–C
C–P
bonds
while
demonstrating
excellent
functional
group
tolerance.
Mechanistic
studies
revealed
that
a
radical-addition–coupling–elimination
cascade
process
was
involved
in
this
reaction.
Язык: Английский
Organocatalytic radical aminoacylation of alkenes for β-aminoketone synthesis
Ayisenbati Jialingbieke,
Xinying Hu,
Z. Liu
и другие.
Science China Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Язык: Английский
Dicarbofunctionalization of Vinylarenes with Pyridine and Aldehydes via Photocatalytic Hydrogen Atom Transfer
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(21), С. 15877 - 15883
Опубликована: Окт. 14, 2024
We
describe
a
metal-free
and
mild
three-component
reaction
utilizing
vinylarenes,
alkyl
aldehydes,
4-cyanopyridine.
In
this
reaction,
the
scope
of
vinylarenes
aldehydes
includes
over
40
examples,
generating
variety
β-pyridinyl
ketones.
Moreover,
potential
applications
method
have
been
demonstrated
by
functionalization
pharmaceutical
molecules.
An
acyl
radical
is
proposed
to
be
produced
via
polarity-matched
hydrogen
atom
transfer
between
triplet-state
diradical
from
benzophenone.
Язык: Английский