Gold-Catalyzed 1,2-Carboxyarylation of Alkenes

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Herein, we disclose an unprecedented gold-catalyzed 1,2-carboxyarylation of alkenes through ligand-enabled Au(I)/Au(III) catalysis. Unlike other approaches for the arylative functionalization C-C multiple bonds, attempts to utilize weak nucleophiles such as carboxylate anions were unsuccessful. The key achieving this transformation is use a 1,3-diketone-appended alkene, which undergoes oxyarylation followed by retro-aldol reaction afford product. Detailed mechanistic investigations conducted support proposed mechanism.

Язык: Английский

Synthesis of α-ketoamides via oxidative amidation of Diazo Compounds with O-benzoyl hydroxylamines as Nitrogen Source and Oxidant

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(33), С. 6708 - 6712

Опубликована: Янв. 1, 2024

An efficient method for the construction of an array α-ketoamides has been described from readily available O -benzoyl hydroxylamines and diazo compounds as starting materials by combined use CuI a catalyst H 2 oxygen source.

Язык: Английский