Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes DOI

Quanjian Luo,

Han‐Chi Wang,

Jierui Zhou

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

We successfully reported selective C–H alkynylation of 2-pyridones with bromoalkynes under the catalysis Co(III) or Ru(II). The reaction used easily accessible instead high-valent iodine alkynes. There is a broad substrate scope good yields. In addition, 2-pyridone can be as weakly directing group for proximal aryl bond. This method offers an efficient approach synthesizing diverse derivatives, yielding alkynylated products up to 95% yield (>40 examples).

Язык: Английский

Metal‐Free Regioselective Direct C(4)−H Amination of Quinazoline with N‐fluorobenzenesulfonimide DOI
Yong Wang,

Xueying Lin,

Xianyu Ying

и другие.

ChemPlusChem, Год журнала: 2024, Номер 89(11)

Опубликована: Июль 18, 2024

Abstract A facile C−H amination of quinazoline employing N ‐fluorobenzenesulfonimide (NFSI) as the source has been disclosed in absence any metal, oxidant or additive. The methodology shows a board range quinazolines with different functional groups moderate to good yields up 87 %. Furthermore, gram‐scale reaction, desulfonylation amine and synthesis pharmaceutical intermediate were also investigated, which demonstrates potential applications medicinal chemistry. plausible mechanism is proposed via F + transfer accompanied by removal one molecule PhSO 2 F. DFT studies experimental work suggest that more favorable than free radical one.

Язык: Английский

Процитировано

1
A Portal to Highly Valuable Pyridonyl Vinyl Sulfonyl Fluorides and Aliphatic Sulfonyl Fluorides DOI
Hua‐Li Qin,

Shan Zeng,

Eman Fayad

и другие.

Synthesis, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract A novel and efficient method for selective Michael addition of 2-pyridones to ethenesulfonyl fluoride (ESF) 1-bromoethene-1-sulfonyl (BESF) has been developed constructing a class pyridonyl aliphatic sulfonyl fluorides vinyl in good excellent yields. This practical features easy operation, wide substrate scope, mild reaction conditions.

Язык: Английский

Процитировано

0
Cs2CO3‐Catalyzed Multi‐Component One‐Pot Stepwise Route for the Synthesis of Polysubstituted 2‐Pyridones DOI
Shitao Liu, Chixian He, Guijun Li

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(45)

Опубликована: Ноя. 30, 2024

Abstract A concise and practicable route to the synthesis of multisubstituted 2‐pyridones via a four‐component one‐pot stepwise cyclization catalyzed by Cs 2 CO 3 has been developed. During this transformation, two new C‐C bonds C‐N were generated through an intermolecular condensation/aza‐Michael reaction/intermolecular Michael addition/intramolecular sequence. The alternative protocol offers complementary provide series structurally diverse polysubstituted (21 examples) in good excellent yields (52–81%) from easily available raw materials arylamines, dialkyl acetylenedicarboxylate, 1,3‐dicarbonyl compounds, trialkyl orthoformate under mild conditions. It might opportunities for discovery 2‐pyridones‐containing drugs.

Язык: Английский

Процитировано

0
Co(III) or Ru(II)-Catalyzed Selective C–H Alkynylation of 2-Pyridones and Their Derivatives with Bromoalkynes DOI

Quanjian Luo,

Han‐Chi Wang,

Jierui Zhou

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

We successfully reported selective C–H alkynylation of 2-pyridones with bromoalkynes under the catalysis Co(III) or Ru(II). The reaction used easily accessible instead high-valent iodine alkynes. There is a broad substrate scope good yields. In addition, 2-pyridone can be as weakly directing group for proximal aryl bond. This method offers an efficient approach synthesizing diverse derivatives, yielding alkynylated products up to 95% yield (>40 examples).

Язык: Английский

Процитировано

0