Gold-Catalyzed Double Spirocyclization of 3-Ene-1,7-diyne Esters to Dispiroheterocycles

Organic Letters, Год журнала: 2024, Номер 26(15), С. 3252 - 3257

Опубликована: Апрель 8, 2024

A synthetic method to prepare dispiroheterocycles containing two all-carbon quaternary centers efficiently that relies on the gold(I)-catalyzed double spirocyclization of 3-ene-1,7-diyne esters is described. The suggested mechanism delineates a rare example dispirocyclization featuring 1,n-acyloxy shifts comprising 1,3-acyloxy migration and an interrupted 1,5-acyl was achieved with assistance residual water in reaction media.

Язык: Английский

Construction of Diverse Fused Chromene Frameworks via Isocyanide-Based Three-Component Reaction

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10854 - 10866

Опубликована: Июль 12, 2024

A convenient synthetic protocol for diverse fused chromenes was successfully developed by a three-component reaction of alkyl isocyanides, dialkyl but-2-ynedioates, and various cyclic 1,3-dipolarophiles containing

Язык: Английский

Rhodium(I)-Catalyzed Cascade Annulation of 1,n-Diynyl Nitrones to 3,4-Fused Fully Substituted Furans

Organic Letters, Год журнала: 2024, Номер 26(31), С. 6631 - 6636

Опубликована: Авг. 1, 2024

A method for the assembly of fully substituted furans containing a 3,4-fused 5–8-membered carbocycle, heterocycle, or spirocycle from rhodium(I)-catalyzed and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)-assisted cascade annulation 1,n-diynyl nitrones has been developed.

Язык: Английский