Recent Advances in the Synthesis of Sulfonamides Intermediates
Pharmaceutical Fronts,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
Abstract
Sulfonamides
are
one
of
the
most
important
synthons
in
drug
synthesis,
which
can
increase
water
solubility
drugs
and
regulate
their
metabolism
vivo.
According
to
statistics,
nearly
30%
sulfur-containing
on
market
contain
sulfonamide
groups,
including
omeprazole,
hydrochlorothiazide,
other
best-selling
drugs.
Synthesis
is
therefore
a
very
part
new
development
active
pharmaceutical
ingredient
manufacturing.
In
this
review,
we
will
focus
recent
5-year
advances
field
synthetic
research
structural
modification
sulfonamide-containing
intermediates.
The
synthesis
strategies,
S−N
construction,
C−N
cross-coupling,
N−H
functionalization,
C−H
sulfonamidation,
discussed,
hoping
provide
ideas
for
researchers
prepare
sulfonamides
green
efficient
way.
Язык: Английский
Sulfonylation/cyclization of alkynes with sulfonyl chlorides by copper catalysis
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(47), С. 19746 - 19749
Опубликована: Янв. 1, 2024
A
gentle
and
remarkably
effective
copper-catalyzed
method
for
the
cascade
sulfonylation
of
alkynes
using
sulfonyl
chlordies
as
direct
sulfonylating
reagents,
is
presented.
Язык: Английский
Recent applications of phenyl hydrazine in photoinduced chemical transformations
Synthetic Communications,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Дек. 3, 2024
Phenyl
hydrazine
has
attracted
attention
in
photoredox
catalytic
synthetic
strategies
for
the
formation
of
carbon-carbon
(C-C)
bond
and
Carbon-Heteroatom
(C-N,
C
=
N,
C-P,
C-S,
S-N)
bonds,
because
low
cost
ease
availability
make
it
a
promising
alternative
method
typical
transition
metal
complex-based
photocatalyzed
synthesis.
In
this
review,
we
have
focused
on
recent
radical
coupling
reactions
phenyl
via
photochemical
to
form
carbon–carbon
carbon–heteroatom
(N,
P,
S)
bonds
along
with
mechanism
involved
their
reaction.
Язык: Английский
Overview of Phenylhydrazine‐Based Organic Transformations
ChemistrySelect,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 30, 2024
Abstract
Phenylhydrazines,
comprised
of
a
phenyl
group
attached
with
hydrazine
unit,
contribute
potentially
to
organic
synthetic
transformations.
Because
the
myriad
applications,
last
decade
has
witnessed
considerable
upsurge
interest
perform
various
reactions
catalyzed/mediated/promoted
by
phenylhydrazines.
Some
these
have
shown
high
regioselectivity
in
short
reaction
time
under
mild
conditions.
The
emergence
innumerable
transformations
utilizing
phenylhydrazine
unleashed
numerous
openings
for
development
diverse
heterocyclic
scaffolds.
Given
importance
this
valuable
chemical
entity,
review
highlights
methodologies
Moreover,
present
article
will
considerably
synthesis
as
well
pharmaceutical
chemistry.
Academically,
be
interesting
and
informative
researchers
attempting
develop
new
routes
structures.
Язык: Английский