The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(16), С. 11588 - 11592

Опубликована: Авг. 4, 2024

This work reports a method for the catalytic synthesis of C(3) SCF3-substituted pyrrolidinindoline using small-ring organophosphorus-based catalyst and hydrosilane reductant, with trifluoromethanesulfonyl chloride as electrophilic SCF3 reagent. can drive conversion tryptamine to pyrrolidine indoline. The readily available, inexpensive could be activated an source by PIII/PV redox catalysis efficiently participate in reaction tryptamines, thus providing various substituted pyrrolidinoindoline moderate excellent yields. presented strategy features broad substrate scope, structure has value in-depth research.

Язык: Английский