Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

A KOtBu-promoted [4+2] annulation-dehydration cascade reaction has been developed, enabling the efficient synthesis of diverse 2-pyridone-fused uracils through a vinylogous enolization strategy involving o-quinodimethane (oQDM) dienolate intermediates. This method provides simple yet robust approach for constructing structurally interesting fused N-heterocycles that incorporate two privileged scaffolds, both which are widely recognized in drug discovery. Consequently, these compounds hold significant potential biological and pharmacological applications. Moreover, further transformations products obtained from this process allow access to highly functionalized uracil derivatives, expanding scope accessible chemical diversity.

Язык: Английский